Merck
2024 University Recruiting - Computational or Structural Chemistry Intern
This job is now closed
Job Description
- Req#: R256896
- Candidates must be currently enrolled in a Bachelor's degree program or higher education in chemistry, biochemistry, biophysics, informatics, computer science, applied mathematics (for Modeling & Informatics positions) or related field
- Candidates must have completed at least two (2) years of studies towards a Bachelor's degree OR at least one (1) year towards a Master’s/Ph.D. by June 2024
- Candidates must be continuing their education after internship completes
- Candidate must have interest/experience in research areas relevant to the drug discovery process
Candidates must be able to commit to full-time onsite employment for 10 - 12 weeks beginning June 2024
Candidates must have basic laboratory skills and research experience such as: protein biochemistry, biophysics, molecular biology, protein expression and purification, protein characterization using biochemical and biophysical techniques, and safe lab practices (for Protein & Structural Chemistry positions)
Candidates should have significant interest in applying modeling/informatics methods towards drug discovery research (M&I)
Candidates should have Programming skills (M&I)
Candidates should have significant interest in protein structure/function (PSC)
Candidates should have experience with preparation of challenging biological macromolecules such as membrane proteins and biologics (PSC)
Candidates should have GPA of 3.0 or higher
Job Description
The Future Talent Program features internships that last 10 - 12 weeks and will include one or more projects. These opportunities in our Research & Development Division can provide you with great development and a chance to see if we are the right company for your long-term goals.
For the candidate: These positions in our Company's Research Labs will provide you with a great development opportunity and a chance to see if we are the right company for your long-term goals.
For our organization: We get to meet the best and brightest individuals who represent the future of scientific endeavor in the US.
We are seeking candidates with a passion for scientific research, excellent academic performance, communication skills, teamwork, and the ability to work in a multi-functional environment. A strong science background in applied laboratory settings, computer science or cheminformatics is essential. Applicants with previous research experience in the listed areas are highly preferred. You will be provided with laptops/lab equipment etc. as necessary to perform the role. This is a paid internship targeted to start in June 2024 and run for 10-12 weeks. Potential involvement in a scientific publication may occur as a result of the research undertaken during the internship.
The departments of Modeling & Informatics (M&I) and Protein & Structural Chemistry (PSC) which consists of a Protein Chemistry group and Structural Chemistry groups are offering internships in the following disciplines:
Modeling & Informatics (M&I) - (Boston, MA; Rahway, NJ; West Point, PA; South San Francisco, CA)
The candidate will participate in molecular modeling and cheminformatics research, either in an independent project or as part of a drug discovery team. Prior experience with molecular modeling approaches such as docking, molecular dynamics, protein design, quantum chemical calculations, and machine learning will be beneficial. The candidate will learn how to employ data, models, and methods to drive hypothesis-driven drug discovery and will be exposed to many areas of research relevant to the drug discovery and development process.
Protein & Structural Chemistry: (PSC) - (Boston, MA; Rahway, NJ; West Point, PA; South San Francisco, CA)
The Structural Chemistry groups use X-ray crystallography and Cryo-electron microscopy to determine structures of drug/target complexes, biologics, and other relevant biological macromolecules to enable structure-based drug discovery. The successful candidate will work to support drug discovery with structural information using some or all of the following methods: protein production in prokaryotic and/or eukaryotic expression systems, preparative protein purification, labeling, characterization using SDS-PAGE, spectroscopic and analytical chromatographic methods, biochemical and biophysical pre-crystallization assays, and crystallization screening and/or sample preparation for Cryo-EM, and structure determination/analysis.
Protein & Structural Chemistry: (PSC) - (West Point, PA only)
The Protein Chemistry group enables crystallography and cryo-EM structural studies by providing high quality, well characterized recombinant proteins throughout our Company. The PSC department also develops methods for directed evolution of recombinant proteins with increased stability as well methods for membrane protein stabilization. The successful candidate will be involved in cloning, expression, purification, and biophysical characterization of recombinant proteins to support various drug discovery activities. Some molecular biology or protein chemistry lab experience is required for this position.
Interns will be responsible for accurate electronic notebook recording, safe laboratory practices, and presentation of data and their interpretation to a team of scientists. The intern will also attend departmental and team meetings to gain a wider perspective of the drug development process in the pharmaceutical industry.
NOTE: Internships are available in Boston, MA, Rahway, NJ, West Point, PA or South San Francisco, CA based on candidate preference. If a candidate is selected for an interview, be prepared to submit letters of recommendation, a brief research statement, and a copy of your transcript. Candidate should select location preference as well.
Education:
Required Experience and Skills:
Preferred Experience and Skills:
Under New York City, Colorado State, Washington State, and California State law, the Company is required to provide a reasonable estimate of the salary range for this job. Final determinations with respect to salary will take into account a number of factors, which may include, but not be limited to the primary work location and the chosen candidate’s relevant skills, experience, and education.
Expected salary range:
$39,600.00-$105,500.00
FTP2024
MRL2024
Employees working in roles that the Company determines require routine collaboration with external stakeholders, such as customer-facing commercial, or research-based roles, will be expected to comply not only with Company policy but also with policies established by such external stakeholders (for example, a requirement to be vaccinated against COVID-19 in order to access a facility or meet with stakeholders). Please understand that, as permitted by applicable law, if you have not been vaccinated against COVID-19 and an essential function of your job is to call on external stakeholders who require vaccination to enter their premises or engage in face-to-face meetings, then your employment may pose an undue burden to business operations, in which case you may not be offered employment, or your employment could be terminated. Please also note that, where permitted by applicable law, the Company reserves the right to require COVID-19 vaccinations for positions, such as in Global Employee Health, where the Company determines in its discretion that the nature of the role presents an increased risk of disease transmission.
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U.S. Hybrid Work Model
Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, generally Tuesday, Wednesday and either Monday or Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence. This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as “remote”.
Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.Employee Status:
Intern/Co-op (Fixed Term)Relocation:
No relocationVISA Sponsorship:
NoTravel Requirements:
No Travel RequiredFlexible Work Arrangements:
Shift:
1st - DayValid Driving License:
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Merck & Co., Inc.,
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