• Job Description

  Req#: 25-10081
  
  Job Title: Bioinformatics Scientist - II
  Duration: 23 months, 40 hrs / week
  Location: Cambridge, MA 02141
  
  Qualifications:
  Required Qualifications:
  • Ph.D. in Computational Biology or a related field.
  • A proven track record of over 3 years in multi-omics analysis.
  • Fundamental understanding of statistical methods and multi-omics data analysis and integration (e.g., RNA-Seq, single-cell RNA-Seq, genotype, spatial transcriptomics, OLINK).
  • Proficiency in R, Python, and Bash, with the ability to establish best practices for reproducible data analyses.
  • Experience with high-performance computing (HPC) systems and AWS Cloud Computing (e.g., IAM, S3 buckets).
  • A collaborative and self-motivated individual with a strong work ethic, capable of managing multiple objectives in a dynamic environment and adapting to changing priorities.
  • Excellent written and verbal communication skills.
  
  Preferred Qualifications:
  • Experience in processing and analyzing real-world data.
  • Familiarity with spatial transcriptomics analysis.
  • Knowledge of statistical and population genetics principles.
  
  Responsibilities:
  Location: Cambridge, MA
  Key Responsibilities:
  • Data Ingestion: Query external databases to acquire relevant multi-omics datasets (e.g., PubMed, Gene Expression Omnibus, ArrayExpress, gnomAD, GTEx, Ensembl).
  • RNA-seq Analysis: Perform quality control (QC) and analysis of bulk and single-cell RNA-seq data using state-of-the-art methods (e.g., FastQC, STAR, Limma, DESeq2, clusterProfiler, Seurat, scanpy, LeafCutter).
  • Multi-Omics Analysis: Analyze diverse molecular data types including spatial transcriptomics (e.g., Slide-seq, MERFISH, squidpy) and proteomics (e.g., OLINK, mass spectrometry-based approaches).
  • Data Integration: Integrate multi-omics datasets, including gene/protein expression, mRNA splicing, spatial transcriptomics, and genotype data.
  • Documentation: Prepare detailed documentation of analysis methods and results in a timely manner.
  

• About the company

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