• Job Description

  Req#: 202211-140239

  The Position

  In Roche's Pharmaceutical Research and Early Development organisation (pRED), we make transformative medicines for patients in order to tackle some of the world’s toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicines. Together, we create a culture defined by curiosity, responsibility and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed.

  This position is anchored into Lead Discovery (LD) in Small Molecule Research (SMR). LD is accountable for the discovery of high quality starting points for drug discovery projects and generates reliable and robust data that enables their successful progression through the preclinical research stages. LD generates molecular and mechanistic insights that are critical for the advancement of discovery projects.

  The position holder will be member of the newly formed cross-functional RNA Hub, where disease-biologists, non clinical development experts, molecular biologists, molecule engineers, bioengineers and data scientists from various pRED functions join together to create and apply technologies that perturb RNA to discover drugs, biomarkers and targets.

  The RNA Hub takes a very data-centric approach, utilizing both artificial and human intelligence, that requires a high degree of data-literacy. In the RNA Hub, we build a strong, collective and engaged community, where we employ, explore and evolve new ways of working in a research environment.

  Role Mission

  We are offering an outstanding opportunity for a Cellular Assay Associate/Scientist Oligonucleotides to work within a multidisciplinary team of scientists dedicated to initiating and implementing novel drug discovery projects,and to jointly shape our future portfolio as a member of a broad network of drug discovery specialists.

  Your Impact

  • Design, develop and perform cell-based assays for screening and profiling of primarily oligonucleotides (single stranded antisense oligonucleotides, gapmer, blockmer, siRNA).

  • Develop target-specific cellular and molecular biology assays for hit triage using multiple technologies such as qPCR, ddPCR, HTRF, ELISA, Imaging, etc.

  • Design and implement cell-based assays using primary cells and iPSCs derived models to assess potency, specificity and in vitro safety.

  • Apply state-of-the-art cell engineering technologies to develop cellular tools for screening and profiling.

  • Use NGS methods for characterization and profiling of on- and off-targets

  • Act as a central character for all Lead Discovery efforts for oligonucleotide research leading/coordinating oligonucleotide activities and potentially drug discovery projects; internal and/or in collaboration with external partners

  • Nurturing trustful relationships and effective collaboration with internal and external partners.

  Your Profile

  You thrive in a dynamic, inclusive environment which gives you full accountability for your own contributions and development. You have a keen interest in continuously building a personal network. You are resourceful and flexible in problem solving and in working in a collaborative and inclusive manner. You have a sense for ensuring that everyone has the required information at all times.

  You are an enthusiastic scientist with a background in cell biology, molecular biology or relevant life science field. You bring interest and expertise in the application of a large spectrum of technologies in cell based assays. Your academic or industry experience in in vitro testing and characterization of oligonucleotides allows you to support project teams with functional assays from the project idea to optimization of clinical candidate oligonucleotides.

  You have strong oral and written communication skills and are proficient in working with cross-functional and multidisciplinary teams.

  Our commitment

  Roche commits to recognizing talent and aptitude. We prioritize encouraging and supporting our employees on their personal journeys by providing a safe, creative space to help them reflect, make decisions and grow in their career.

  We are confident that we find the most innovative solutions by gaining different perspectives, asking and answering hard questions, and challenging the status quo. Roche embraces diversity and equal opportunity in a serious yet enthusiastic way; we are devoted to building a team that represents a range of backgrounds, perspectives, and skills. The more inclusive we are, the better our work will be.

  Who we are

  At Roche, more than 100,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.

  Basel is the headquarters of the Roche Group and one of its most important centres of pharmaceutical research. Over 10,700 employees from over 100 countries come together at our Basel/Kaiseraugst site, which is one of Roche`s largest sites. Read more.

  Besides extensive development and training opportunities, we offer flexible working options, 18 weeks of maternity leave and 10 weeks of gender independent partnership leave. Our employees also benefit from multiple services on site such as child-care facilities, medical services, restaurants and cafeterias, as well as various employee events.

  We believe in the power of diversity and inclusion, and strive to identify and create opportunities that enable all people to bring their unique selves to Roche.

  Roche is an Equal Opportunity Employer.

• About the company

  606018 F. Hoffmann-La Roche AG is a Swiss multinational healthcare company that operates worldwide under two divisions: Pharmaceuticals and Diagnostics.

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