Job Description: Clinical Scientist, Early Clinical Development, Early CVRM

Location: Office based hybrid role in Gaithersburg MD

Are you an experienced scientist with clinical research experience in cardiovascular and/or kidney disease? Join AstraZeneca and be part of an impactful team of cross functional clinical research professionals translating scientific discoveries into early phase clinical development programs across a wide range of chronic and debilitating diseases.

AstraZeneca, is dedicated to being a great place to work with an inclusive and diverse team of amazing colleagues who work in a dynamic collaborative work environment. We are dedicated to improving the healthcare and quality of life for patients; developing innovative therapies that address unmet clinical needs and that provide clinicians with novel evidence-based treatment options that will enable them to optimize patient care.

Who We Are:

In Cardiovascular, Renal & Metabolism (CVRM), we are investigating the drivers of CVRM disease progression through ground breaking scientific methods and data-driven drug discovery and development approaches. In this context, the Early Clinical Development team are investigating varying drug modalities from a rich CVRM portfolio across cardiovascular and kidney disease patients.

Early Clinical Development is part of the Early CVRM organization, and is where science meets the patient with a focus upon delivering innovative programs, accelerating human target validation, while collaborating closely with late clinical development and regulatory colleagues who guide pivotal phase 3 clinical studies. We are a team of passionate clinical scientists and physicians who collaborate broadly to establish strategies, design innovative phase I through phase IIb clinical trials, develop and validate novel endpoints, and translate scientific ideas in to a proof of concept in targeted patient populations.

We are looking for an experienced clinical development scientist with clinical research experience in cardiovascular and/or kidney disease. Your ambition to improving patients’ lives will involve you in a team working in a collaborative environment, driving the clinical development of novel innovative therapies in CVRM diseases. This role enables you to work at the forefront of early clinical and translational research in CVRM.

What you will do:

As a clinical scientist your core accountability will be scientific support for the development and maintenance of clinical strategies based upon your established expertise including the latest thinking about mechanisms of disease, diagnostic approaches, current treatment options, drug development trends, and regulatory requirements in relevant disease and therapeutic areas. You will contribute to early phase clinical trials and related clinical research projects for potential therapies that are targeting cardiovascular and kidney diseases, as well as serving as an expert on the design, conduct, monitoring, data interpretation, and reporting of these studies. Additional tasks include supporting regulatory documentation, liaison with discovery scientists, regulatory, clinical and commercial colleagues, developing and managing external collaborations, and developing a deep knowledge of the literature pertaining to the product(s) under development. You will also work on cross-functional teams within our early clinical development group and across the broader early CVRM organization that are framing our strategies and development plans for potential therapies that are targeting major metabolic disorders, given that these disorders intersect with cardiovascular and kidney diseases and influence disease progression.

In this role, you will contribute to cross-functional project teams with multidisciplinary professionals from a diverse range of geographic locations. We will rely on you to:

• Contribute to the design and operational implementation of early-stage clinical projects ensuring programs under your purview are scientifically meticulous, clinically sound, operationally successful, and adhere to GCP and regulatory requirements.
• Collaborate closely with other groups within early CVRM to provide expert clinical input into pre-clinical scientific activities such as target selection, lead generation and optimization, clinical pharmacology and in vivo/in vitro studies.
• Work collaboratively with highly capable teams of physicians and clinical scientists who design scientifically thorough clinical studies aligned with pre-clinical scientific findings and development plans for each potential therapy, while ensuring seamless transition of early clinical programs to late stage development.
• Assist with the preparation, review and maintenance of project documents including those for regulatory authorities.
• Contribute to interactions with external collaborators related to CVRM early phase clinical programs and studies.
• Collaborate on efforts to certify and validate the scientific evidence for surrogate endpoints used in the studies including imaging, digital, and biomarker endpoints.
• Serve as scientific expert communicating and disseminating the scientific accomplishments of early clinical development team through internal forums, presentations at scientific meetings and publications.
• Communicate and interaction with external clinical and scientific experts for cardiovascular and kidney disease and integrate input from external advisors into our clinical development plans, scientific discovery efforts, and regulatory interactions.
• Chip in to continuous efforts to enhance operational planning and execution of early phase clinical studies, including developing innovative approaches for engaging and supporting clinical trial sites.

Education and Experience Required:

You will be an experienced scientist with a PhD qualification, potentially also with additional masters or doctoral degrees.

You should have at least 3 years’ experience working in a clinical research setting and a good publication track record. You should have a demonstrated scientific knowledge in either cardiovascular and/or kidney disease. Plus, evidence of strong collaborative working, a delivery focus and strong expressive and receptive communication skills.

We are eager to know more about you. If you are interested to know more about us, apply now!

For more information please contact recruiting manager Peter Greasley Group Director ECD Clinical Scientists at +46317761633 or peter.greasley@astrazeneca.com

AstraZeneca – An Employer of Choice

AstraZeneca embraces diversity and equality of opportunity. Our commitment is to build an inclusive and diverse team representing all backgrounds and perspectives. We believe that the more inclusive we are, the better our work will be. We encourage and consider applications to join our team from all qualified candidates, regardless of their characteristics.

We offer a competitive Total Reward program including a market driven base salary, bonus and long term incentive. We also provide a generous paid time off program and a comprehensive benefits package! If you have the determination to build a culture of courageous leadership, creativity and collaboration, apply today.

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or parental leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law. AstraZeneca only employs individuals with the right to work in the country/ies where the role is advertised.

Where can I find out more?

AstraZeneca Gaithersburg: https://www.astrazeneca.com/our-company/our-locations/gaithersburg.html

CVRM at AstraZeneca: https://www.astrazeneca.com/our-therapy-areas/cardiovascular-renal-and-metabolism.html

This is what we’re made of: https://www.youtube.com/watch?v=pmFx_jr2eFo&t=2s

Recent Publications: https://www.astrazeneca.com/publication.htm

Date Posted

18-Mar-2024

Closing Date

16-Apr-2024Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.

AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.