• Job Description

  Req#: 393052

  GSK is seeking a highly motivated scientist to join the multidisciplinary Encoded Technologies (ET) team. As a member of the ET Affinity Selections and Biophysics Group, you will support small molecule drug discovery programs across GSK with specific accountability for biophysical aspects of hit discovery and validation, and further developing platform capabilities. Additionally, you will represent the group providing biophysics expertise to cross-functional project teams.

  The successful candidate will have substantial, hands-on experience with various biophysical (e.g., SPR, MST, DSF, DLS, FP, alphaLISA, trFRET, switchSENSE) and biochemical (e.g., mass spectrometry, analytical chromatography, SDS-PAGE) techniques. Experience with targeted protein degradation, molecular glues, covalent probes, interrogation of cell lysates, membrane-bound proteins, and/or oligo therapeutics (e.g,. ASOs, AIMers) is a plus. This experience could be from an academic, biotechnology, or pharmaceutical industry setting. We seek a critical thinker with a demonstrated ability to work in teams, effectively communicate science, pursue and prioritize multiple projects simultaneously, and deliver high quality results on time.

  GlaxoSmithKline is a world leading research-based pharmaceutical company that combines both individual talent & technical resources to create a platform for the delivery of strong growth in a rapidly changing healthcare market. Our mission is to improve the quality of human life by enabling people to do more, feel better, & live longer. GSK is headquartered in London, UK with operations in the US; this opening is located at the Cambridge, MA, USA site.

  This role will provide YOU the opportunity to lead key activities to progress YOUR career, these responsibilities include some of the following…

  • Accountable for the design, execution, and data analysis of biophysical assays to support small molecule hit identification staregy for genetically validated drug targets
  • Develop a deep understanding of affinity-based screening and contribute to the advancement of a discovery platform that builds off GSK’s investments in genetics and technology
  • Represent the team on multidisciplinary drug discovery and platform development projects locally and with GSK colleagues across multiple R&D sites, worldwide
  • Contribute to publications, presentations, and collaborations that enhance the visibility of the team
  • Ensure compliance with all GSK R&D data integrity practices, ethics codes, work practice training and standards.

  Why you?

  Basic Qualifications:

  We are looking for professionals with these required skills to achieve our goals:

  • PhD or an MS plus 3 years of relevant experience in molecular biophysics, biochemistry, or related fields.

  Preferred Qualifications:

  If you have any of the following characteristics, it would be a plus:

  • Molecular biophysics research experience with the structure, function, and dynamics of proteins and protein complexes; protein-ligand, protein-protein, and protein-DNA binding; or membrane-bound proteins
  • Hands-on experience with affinity selection screening techniques, especially DNA Encoded Libraries (DEL) technologies or affinity selection mass spectrometry (ASMS).
  • Hands-on experience in biophysical binding techniques, especially SPR (using a Carterra LSA), MST, nanoDSF, alphaLISA, trFRET, and other related assays.
  • Hands-on experience with robotic liquid handlers (e.g., Agilent Bravo)
  • Demonstrated ability to formulate and implement strategic research plans
  • Demonstrated written and oral communication skills, including publications in peer reviewed journals and presentations at scientific conferences
  • Strong data literacy, including large data set analysis and visualization skills, including experience with R, python, or equivalent, and/or Spotfire.
  • Demonstrated strengths in high performance behaviors, such as building relationships, flexible thinking, and enabling/driving change
  • Demonstrated scientific leadership.

  Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.

  Why Us?

  GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organization where people can thrive. Getting ahead means preventing disease as well as treating it, and we aim to positively impact the health of 2.5 billion people by the end of 2030.

  Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a workplace where everyone can feel a sense of belonging and thrive as set out in our Equal and Inclusive Treatment of Employees policy. We’re committed to being more proactive at all levels so that our workforce reflects the communities we work and hire in, and our GSK leadership reflects our GSK workforce.

  If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US).

  GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.

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• About the company

  GlaxoSmithKline plc is a British multinational pharmaceutical company headquartered in Brentford, England.

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