Genentech
Postdoctoral Fellow - Proteomics of Neurodegeneration, Ori/Bingol Labs
This job is now closed
Job Description
- Req#: 202310-123629
A position is available for a postdoctoral fellow with expertise in neuroscience, iPSC-derived models, and omics data to join the Departments of Microchemistry, Proteomics & Lipidomics + Next Generation Sequencing, and Neuroscience at Genentech, Inc. We have cutting edge facilities in-house for proteomics, lipidomics, NGS, CRISPR screens, in vitro and in vivo models, and computational biology.
Responsibilities:
Active areas of research include high-throughput proteome profiling of iPSC-derived brain cell types, mechanistic investigation of disease relevant proteoforms and organelle proteomics. The project will entail a combination of unbiased discovery and hypothesis driven research to derive causal relationships between pathways contributing to neurodegeneration. The successful candidate will be responsible for generation of large-scale datasets, derivation of causal models and follow up mechanistic investigations of novel findings. The candidate will work at the interface between disciplines and leverage expertise from different research areas including proteomics, functional genomics, computational biology and neuroscience.
Who You Are:
Team player with a fearless attitude to tackle long standing, difficult problems in neuroscience. Highly motivated and capable of independent work in a collaborative and multidisciplinary environment. Strong background in culturing and manipulating iPSC-derived models, CRISPR screens or neuroscience as evidenced by a first author paper published or accepted in peer-reviewed journals. Strong computational skills would be advantageous. Previous experience with proteomics is not required.
Candidates must have a Ph.D. in biology, biophysics, biochemistry or a related discipline.
For information about the Postdoctoral Program at Genentech, please go to:
https://www.gene.com/careers/university-and-early-career/postdocs
Relevant publications:
Di Fraia, D., Marino, A., Lee, J.H., Kelmer Sacramento, E., Baumgart, M., Bagnoli, S., Tomaz, P., Sahu, A.K., Siano, G., Tiessen, M., Terzibasi-tozzini, E., Gagneur, J., Frydman, J. #, Cellerino, A.#, and Ori, A.# (2023). A comprehensive atlas of the aging vertebrate brain reveals signatures of progressive proteostasis dysfunction. bioRxiv 2023.07. 20.549210.
Laqtom, N.N., Dong, W., Medoh, U.N., Cangelosi, A.L., Dharamdasani, V., Chan, S.H., Kunchok, T., Lewis, C.A., Heinze, I., Tang, R., Grimm, C., Dang Do, A.N., Porter, F.D., Ori, A., Sabatini, D.M.#, and Abu-Remaileh, M.# (2022). CLN3 is required for the clearance of glycerophosphodiesters from lysosomes. Nature 609, 1005–1011.
Kelmer Sacramento, E., Kirkpatrick, J.M., Mazzetto, M., Baumgart, M., Bartolome, A., Di Sanzo, S., Caterino, C., Sanguanini, M., Papaevgeniou, N., Lefaki, M., Childs, D., Bagnoli, S., Terzibasi Tozzini, E., Di Fraia, D., Romanov, N., Sudmant, P.H., Huber, W., Chondrogianni, N., Vendruscolo, M., Cellerino, A.#, and Ori, A.# (2020). Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation. Mol. Syst. Biol. 16, 1–22.
For information about Ori Lab at Genentech, please go to:
https://www.gene.com/scientists/our-scientists/alessandro-ori
For information about Bingol Lab at Genentech, please go to:
https://www.gene.com/scientists/our-scientists/baris-bingol
The expected salary range for this position based on the primary location of California is $64,800 and $120,300. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. This position also qualifies for the benefits detailed at the link provided below.
Relocation benefits are available for this job posting.
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Genentech is an equal opportunity employer, and we embrace the increasingly diverse world around us. Genentech prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status.
About the company
Genentech, Inc., is an American biotechnology corporation which became a subsidiary of Roche in 2009.
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