Introduction to Role:

AstraZeneca is on the lookout for a dynamic and innovative Principal Scientist to join our Immuno-Oncology Discovery team in Waltham, MA. This role is an exciting opportunity to be part of a team that is at the forefront of designing, testing, and developing biologic therapeutics. As a Principal Scientist, you will play a pivotal role in supporting Immuno-Oncology projects through the drug discovery process, leading novel drug discovery programs from inception, and delivering datasets that directly impact pipeline programs.

Accountabilities:

In this laboratory-based position within the Immune Cell Circuits and Engagers group, you will develop, conduct, and analyze experiments to assess the function of our candidate biologic therapies. You will design novel therapeutics targeting the immune system for cancer therapy and help to dissect their mechanism of action. You will also review emerging literature and internal data to help in identifying new potential targets and contribute to target validation activities.

Essential Skills/Experience:

• A PhD in immunology, biochemistry, and/or immuno-oncology, with at least 8 years of post-doctoral experience.
• Strong background in bioengineering to modulate immune function.
• Program leadership experience including the mentoring and managing of junior scientists.
• Mastery of molecular techniques with a relevant focus on protein engineering towards biological function.
• Ability to independently design and implement research plans for one or more programs.
• Strong interpersonal, influencing, negotiating and collaboration skills.
• Understanding and application current gene editing techniques including CRISPR, ZNFs, etc.
• Experience in the generation, analysis, and interpretation of high-dimensional analyses (flow cytometric, bulk and/or scRNA seq).

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

At AstraZeneca, we are committed to pushing the boundaries of science to change the practice of medicine and transform the lives of patients living with cancer. We are a science-based, leading Oncology enterprise united in our vision to eliminate cancer as a cause of death. With one of the broadest and deepest Oncology pipelines in the industry, there are many opportunities to work with new and novel drugs and help discover what's next. We foster a mentality of courage, where everyone is empowered to step up, innovate and work at pace. We lead through true collaboration, building collective wisdom by giving everyone a chance to input. It's science with an impact-making a difference for patients and people around the world.

Are you ready to make a difference? Apply now to join our team!

Date Posted

16-Jul-2024

Closing Date

29-Sep-2024Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.

AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.