Novartis
Research Scientist II, CGT Delivery (AAV & Lentiviral)
This job is now closed
Job Description
- Req#: 389370BR
Position is onsite in San Diego
#LI-Onsite
About the Role
Novartis Biologics Research Center (BRC) is a leader at the cutting edge of innovative medicine development to improve patient lives. BRC builds the biologics pipeline in collaboration with Novartis Biomedical Research (NBR) Disease Areas and Platforms via a breadth of technologies for discovery of antibody, protein, gene therapy and RNA-based therapeutics.
We are seeking a highly motivated scientist to contribute to gene therapy development as part of the global community of investigators in the Cell & Gene Therapy (CGT) group within BRC. The successful candidate will work at the cutting edge of gene therapy delivery platform and technology and contribute to CGT Delivery programs. This role encompasses primarily lab-based responsibilities as outlined below. The scientist will take part in projects that will contribute to the development of novel capsid variants using internally developed screening platforms. The successful candidate with be a collaborative scientist with in-depth experience in cell and molecular biology, knowledge of virology (AAV and LVV) and assay development.
Key responsibilities:
• Participate and perform experiments in CGT Delivery including and not limited to molecular cloning and plasmid library production.
• Operate next-generation sequencing (NGS) platform instrumentation (Illumina, PacBio, etc.) and analyze data from targeted experiments is highly desired.
• Execute molecular biology assays to analyze in vitro and in vivo samples for characterization with techniques such as PCR/qPCR/dPCR, IHC/IF, and/or ELISA/MSD.
• Co-lead in vivo biodistribution and platform analysis projects as part of internal CGT programs.
• Develop molecular biology assays for the specific needs of internal CGT programs.
• Prepare quality data sets and reports adhering to the good research practices and quality culture across BRC.
• Present results at appropriate internal and external meetings and conferences.
*Multiple positions available.About the company
At Novartis, we are reimagining medicine to improve and extend people’s lives. We are working hard to produce breakthroughs and address unmet needs for patients with devastating diseases, including genetic disorders and certain deadly cancers. Learn mo...
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