Novartis
Research Scientist II, Downstream
This job is now closed
Job Description
- Req#: 393017BR
Position is on-site in San Diego, CA
#LI-Onsite
About the role:
The Biologics Research Center (BRC) Cell & Gene Therapy unit at Novartis Biomedical Research in San Diego, California is seeking a motivated Research Scientist II to contribute in early-stage recombinant adeno-associated virus (AAV) gene therapy portfolio. BRC is an innovative hub focuses on building new modalities that tackle complex biology and enable the creation of advanced biotherapeutics, siRNAs and cell & gene therapies to improve patients’ lives. In collaboration within BRC and with Disease Areas, the Cell & Gene Therapy unit brings viral engineering in AAV gene therapy to create transformative medicine.
The prospective Research Scientist will support early-stage AAV gene therapy pipeline portfolio focusing on downstream manufacture developability of novel AAV capsids, executing early-stage downstream method exploration and building improved process technologies for AAV manufacture.
Your Key Responsibilities:
Your responsibilities include, but are not limited to:
• Perform different scales of purification process including depth filtration, ultracentrifugation, AKTA column chromatography, and TFF unit operations for manufacturing of AVV gene therapy vectors across multiple early-stage programs and disease areas to ensure on time delivery.
• Execute experiments to drive innovative technology and platform evaluation for next generation capsids.
• Perform experiment-related activities including buffer preparation, equipment maintenance, sample labelling and analytical sample submissions.
• Work collaboratively with upstream process development and analytical development teams.
• Engage collaboratively in operational and scientific discussion within internal team
• Assist knowledge transfer and work collaboratively with Technical Research & Development team to advance pipeline programs into clinical phases.
• Prepare protocols, reports, and provide high quality data and electronic notebook documentation.
• Other related duties as assigned.
This position will be located at the San Diego, CA site and will not have the ability to be located remotely.About the company
At Novartis, we are reimagining medicine to improve and extend people’s lives. We are working hard to produce breakthroughs and address unmet needs for patients with devastating diseases, including genetic disorders and certain deadly cancers. Learn mo...
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