Today, Lonza is a global leader in life sciences operating across three continents. While we work in science, there’s no magic formula to how we do it. Our greatest scientific solution is talented people working together, devising ideas that help businesses to help people. In exchange, we let our people own their careers. Their ideas, big and small, genuinely improve the world. And that’s the kind of work we want to be part of.

The role:

We are looking for a Scientist with a background in cell expression technologies to join our team in Cambridge to focus on developing next-generation, industrially relevant cell expression platforms. As a Scientist, you can expect to be involved heavily in the development of improved expression systems or services for the production of complex therapeutic proteins and support various R&D projects within Lonza.

Key responsibilities:

• Contribute to the delivery of new CHO-based mammalian expression hosts and vector systems for the expression of complex therapeutic proteins

• Engineer mammalian cell lines (e.g. random integration, targeted integration and gene editing – e.g. CRISPR-based systems).

• Generate mammalian expression vectors using state-of-the-art assembly techniques

• Phenotypic characterization of edited cell lines with relevant assays (e.g. NGS, ddPCR, qPCR and flow cytometry) and cell culture techniques (e.g., shake flask/ bioreactor).

• Collate, analyse, evaluate and sign off data to produce good quality information and traceable records under the direction of the project lead.

• Presentation of results in written and oral reports.

• Work closely with other groups within R&D to deliver solutions or improvements in recombinant protein expression (in particular with R&D Process Development, Microbial Expression & Protein Analytics).

• Actively keep abreast of relevant academic literature (e.g., in the field of cell engineering and expression technologies).

• Contribute ideas and opinions to scientific discussions to aid the development of new technologies.

• Working as a team player and working with a high degree of flexibility.

Key requirements:

• BSc/MSc Degree in Life Sciences / Science/ Molecular Biology or similiar

• Practical experience within R&D in an industrial/academic settings.

• Good technical background in molecular biology (electrophoresis, PCR, vector construction) and cell culture (preferably mammalian cells) to develop or manipulate mammalian expression systems.

• Clear demonstration of strong technical skills, scientific execution, and data analysis.

• Experience in cell line engineering, ideally with CRISPR-based systems would be an advantage.

• Good understanding of automation/NGS (next-generation sequencing) would be desirable.

• Ability to work in cross-functional groups to transfer technology into other groups and support commercialisation.

Every day, Lonza’s products and services have a positive impact on millions of people. For us, this is not only a great privilege, but also a great responsibility. How we achieve our business results is just as important as the achievements themselves. At Lonza, we respect and protect our people and our environment. Any success we achieve is no success at all if not achieved ethically.

People come to Lonza for the challenge and creativity of solving complex problems and developing new ideas in life sciences. In return, we offer the satisfaction that comes with improving lives all around the world. The satisfaction that comes with making a meaningful difference.