• Job Description

  Req#: R-180832

  AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development, and commercialization of prescription medicines for some of the world’s most serious diseases. We are more than one of the world’s leading pharmaceutical companies.

  AstraZeneca has a multifaceted environment that cultivates collaboration and innovation. We attract top minds, and we nurture and build talent. Within Hematology R&D, we are committed to advancing the science to deliver life-changing medicines to patients most in need. With a combination-focused pipeline that exploits the power of multiple scientific platforms (Immuno-Oncology, Tumor Drivers and Resistance, DNA Damage Response, Antibody-drug Conjugates, Cell Therapy, and Epigenetics) to help address unmet clinical needs in a host of hematological cancers, we are motivated by a dedication to the scientific discovery and collaboration that will one day help eliminate cancer as a cause of death. This unit has responsibility for the value chain from discovery through to late-stage development, enabling rapid acceleration of promising early-stage assets and life-cycle management programs.

  The Translational Medicine (TM) function exists within Hematology R&D to ensure effective and strategic biomarker studies for Hematology & Oncology project teams. Closely interacting with the pre-clinical BioScience and Discovery, Early Clinical Development, and Precision Medicine & biosamples diagnostics functions, the Hematology Translational Medicine team is the single point of accountability for the delivery of robust, scientifically-driven biomarkers to all Hematology project teams, providing feasibility assessments, technical validation, centralized biomarker analysis capability for clinical samples, delivery of translational science research and early clinical phase engagement. We are looking for a highly motivated scientist to join the Translational Research, Haematology R&D team and work in close collaboration with the Center for Single Cell Studies (CSCS) in Waltham Massachusetts.

  • Preparing, and executing procedures of single-cell RNA sequencing using different types of specimens.

  • Optimization of methods for single-cell/nuclei sequencing from fresh and archival clinical samples and solving problems during the process.

  • Transition of new technologies from proof-of-concept to standardized workflows.

  • Delivery of reliable and high-quality data and metadata to computational analysis.

  • Synergize with Translational Research Scientists, Translational Medicine Leads and computational biologists.

  • This is a laboratory-based position

  Qualifications:

  • Master’s degree in biological sciences with NGS laboratory experience, or B.A/ B.Sc in life sciences or related field with at least 2 years of relevant experience

  • Hands-on experience in single-cell RNA sequencing techniques required, with exposure to spatial transcriptomics approaches preferred: specimen handling, quality control assessments, droplet-based cell processing, library construction, and sequencing.

  • Deep understanding in immunology, cancer, genomics, and RNA biology.

  • Solid track record of performance, including successful completion of projects within a given timeframe and budget.

  • Outstanding ability to work independently and with a team- including problem solving, brainstorming, integrating data and helping other team members.

  • Excellent organizational and documentation skills.

  • Innovative approach and enthusiasm to explore new technologies.

  Working at AstraZeneca

  Here you’ll have the chance to create a substantial difference in patients’ lives! With science at its heart, this is the place where breakthroughs born in the lab become transformative medicines – for the world’s most complex diseases. Answer unmet medical needs by pioneering the next wave of science, focusing on outcomes, and crafting the patient ecosystem.

  Next Steps? Apply now!

  AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

  Find out more and follow AstraZeneca on:

  LinkedIn https://www.linkedin.com/company/1603/

  Facebook https://www.facebook.com/astrazenecacareers/

  Instagram https://www.instagram.com/astrazeneca_careers/?hl=en

  Date Posted

  20-Dec-2023

  Closing Date

  24-Dec-2023Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.

  AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.

• About the company

  AstraZeneca PLC is a British-Swedish multinational pharmaceutical and biopharmaceutical company with its global headquarters in Cambridge, England.

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