• Job Description

  Req#: R-160626

  Job Description: Scientist-TCR Discovery

  Summary of the group

  The Biologics Engineering (BE) department at AstraZeneca is constantly pushing the boundaries of science to deliver life-changing medicines to patients, with a passion for discovery and a pipeline to show for it. We’re using our expertise in biologics engineering to enable novel therapeutic approaches to Oncology, Respiratory, Inflammatory, Cardiovascular and Infectious disease. We offer a unique and strong collaborative network as part of the AstraZeneca family, as together we explore new and exciting technologies.

  This opportunity

  The Department of Biologics Engineering in Gaithersburg, MD is seeking a talented and highly motivated Scientist to enhance our T cell receptor (TCR) discovery platform. The successful candidate will help build the next-generation discovery engine to rapidly isolate novel TCRs for use as oncology therapeutics. We are seeking a candidate with expertise in conducting in vitro assays to identify tumor specific T cells. The candidate will operate independently and in collaboration with a diverse group of scientists to actively drive technological innovations. The selected individual will be a well-organized and a highly productive bench scientist that can design and execute experiments efficiently, as well as analyze, interpret and present data to multidisciplinary project teams.

  Required Education/Experience

  B.S. in cell biology, molecular biology or other related discipline with 5+ years experience

  OR

  M.S. in cell biology, molecular biology or other related discipline with 0-2 years of relevant research experience in an academic setting.

  Required skills

  • Expertise in primary mammalian cell culture including human T cells and T cell expansion
  • Strong background in functional T cell assays, cytokine profiling assays, T cell cytotoxicity assays, flow cytometry and cell sorting
  • Experience in genetically modifying T cells
  • The individual should have demonstrated experience in optimizing/troubleshooting new protocols with a problem-solving mindset and be adept at learning new platforms and skills.
  • Ability to troubleshoot, optimize and execute experiments independently

  Desired skills

  • Molecular biology techniques, such as cloning, PCR, Sanger sequencing
  • Background in immunotherapy development/T cell biology in a biotech/pharma setting

  Special Skills / Abilities / Knowledge / Behavioral Competencies

  Strong communication skills are highly desirable. The individual should also be self-motivated, embrace new technologies and have demonstrated an ability to work within teams.

  Date Posted

  15-Jun-2023

  Closing Date

  21-Jun-2023

  AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.

  AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.

• About the company

  AstraZeneca PLC is a British-Swedish multinational pharmaceutical and biopharmaceutical company with its global headquarters in Cambridge, England.

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