Scientist, Tumor Targeted Delivery

Are you ready to make a significant impact in the world of oncology? As a Scientist in Targeted Tumor Delivery within Oncology R&D, you will be a key player in supporting oncology projects through the drug discovery and development process. Your experimental and analytical expertise in cancer biology will be crucial in establishing assays and delivering datasets that will directly influence future targeted cancer therapeutics. Join our dynamic team in our state-of-the-art facility in Waltham, MA, just outside Boston. This is your chance to contribute to the next generation of cancer therapies!

Accountabilities:

In this role, you will be part of a team of laboratory-based scientists within the Oncology Research group. You will design, conduct and analyze in vitro experiments to evaluate candidate drug targets and assess the function of candidate oncology drugs. This includes identifying and onboarding relevant disease models and target engagement and efficacy assays. You will execute these assays to help evaluate the pharmacologic effects of compounds of interest. Additionally, you will have opportunities to review emerging literature and internal data to identify new targets and contribute to target nomination, evaluation, and validation activities within the Targeted Tumor Delivery group.

Essential Skills/Experience:

• BS with 5+ years of full-time research experience in Cell/Molecular Biology, Cancer Biology, In vitro Pharmacology or related scientific area. Industry experience strongly preferred.
• OR MS with 2+ years of full-time research experience in Cell/Molecular Biology, Cancer Biology, In vitro Pharmacology or related scientific area. Industry experience strongly preferred.
• Experience executing in vitro studies for the analysis of human tumor cell function.
• Expertise in experimental design and analysis.
• Strong knowledge of cancer biology, cell biology, genetics, cell signaling, and molecular biology.
• Deep understanding of cancer models, particularly cell culture.
• Demonstrated ability to work well independently and to collaborate with teams.
• Ability to report and communicate data in a clear and concise manner.
• Creative problem-solving skills.
• A passion for learning, mentorship, and personal and professional growth.

Desirable Skills/Experience:

• Experience in industry drug discovery program is strongly preferred.
• Hands-on experience designing and developing quantitative, mechanistic, cell-based assays for evaluating compounds for target engagement.
• Cell and Molecular Biology skills including assessment of intracellular signaling, generation of engineered cell lines (CRISPR knock-out/knock-in), generation of cell-based reporter assays, and generation and/or analysis of transcriptomic data.
• Experience with microscopy, flow cytometry, and plate-based medium- to high-throughput assays.

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That’s why we work, on average, a minimum of three days per week from the office. But that doesn't mean we’re not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

Where you’ll be:

Our Boston R&D site, located in Waltham, MA, builds life-changing medicines for people around the world. The modern, vibrant scientific campus employs more than 800 experts in our field and is a key node of the Boston/Cambridge biopharmaceutical hub. The facility is stocked with innovative technology, enabling cutting edge research and collaboration. Our facility was built to foster teamwork, interaction and cross functional science. We believe employees benefit from being challenged, inspired, and supported at work.

The Boston R&D site is situated within a biopharma cluster of academic research institutions, medical centers, pharmaceutical companies and biotech startups. The Boston region is consistently ranked #1 globally for biotech research, investment, talent recruitment and lab space. Site amenities include:

• Modern 64-acre campus nestled in 200+ acres of nature conservation land & hiking trails
• Flexible, agile lab design with co-located office space
• Vibrant site community with activities, clubs, sports & games
• Onsite outdoor activities (e.g. garden club, volleyball, hiking trails etc.)

Why AstraZeneca?

At AstraZeneca, we are on a mission to eliminate cancer as a cause of death. We are pioneers in the field, making bold moves that transform the way cancer is treated and truly improve patient outcomes. With one of the broadest and deepest Oncology pipelines in the industry, there are many opportunities to work with new and novel drugs and help discover what's next. We foster a mindset of courage, where everyone is empowered to step up, innovate and work at pace. We lead through true collaboration, building collective wisdom by giving everyone a chance to input. It's science with an impact-making a difference for patients and people around the world.

Ready to make a difference? Apply today and join us in our mission to eliminate cancer as a cause of death!

Date Posted

23-Apr-2024

Closing Date

Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.

AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.