• Job Description

  Req#: R-173942

  Do you have a passion for science? Would you like to apply your expertise to impact a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be the one for you!

  At AstraZeneca, we put patients first and strive to meet their unmet needs worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you’re our kind of person.

  About AstraZeneca in Gaithersburg, MD:

  Our Gaithersburg, Maryland facility creates life-changing medicines for people around the world. This campus employs more than 3,500 experts in our field and is only a short drive from Washington, DC. This modern and vibrant scientific campus is the home of R&D and Oncology in the US. Here, we play host to some of the most ground breaking technology and lab spaces, all designed to encourage collaboration and cross-functional science. We believe employees benefit from being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration.

  The Gaithersburg site offers a variety of amenities to help boost efficiency and help keep our employees happy and healthy. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center. This is where you’ll find newly designed, activity-based workspaces to suit a variety of working styles while increasing collaboration between teams.

  Summary of the group:

  The Biopharmaceutical Development group is a multi-disciplinary scientific function providing expertise in Process/Analytical/Formulation/Devices Development and Characterization with integrated Bioprocess Engineering, Clinical Manufacturing, and Supply Chain and Logistics operations. The group is also responsible for transferring the processes to different commercial sites in and outside the AstraZeneca organization. BPD group is present in multiple sites including Gaithersburg, MD, and Cambridge UK.

  The Purification Process Sciences Group is accountable for purification and conjugation process development of complex biopharmaceuticals including proteins, monoclonal antibodies, antibody-drug conjugates, nucleic-acid based modalities, vaccines, and viral vectors. This group assists in the scale up and technical transfer of processes to different clinical and commercial sites and supports manufacturing deviations and regulatory submissions as needed.

  Job Description

  The Scientist in this position is encouraged to have a thorough understanding of purification techniques and principles for large biologicals including liquid chromatography, normal and cross flow filtration. The Scientist s expected to design, develop, and execute purification processes to meet early-stage process development objectives and timelines. The candidate is expected to assist in the preparation of regulatory documents.

  • Develop and characterize purification processes for the manufacture of complex biopharmaceuticals including monoclonal antibodies, proteins, DNA, RNA, and viral vectors
  • Documents experiments, data, technical reports, and findings electronically in an accessible manner
  • Presents findings, progress, and data proactively and regularly in group and department meetings
  • Functions with limited supervision and is encouraged to work independently on a day-to-day basis. Expectation for independence will increase with time and experience in the position.

  Education & Experience Requirements:

  Scientist :

  Bachelor's or Master's degree in Biochemistry, Biology, Chemical/Biochemical Engineering, or related field.

  • MS and a minimum of 2+ years of relevant purification process development experience, preferably in a biopharmaceutical industry setting
  • BS and a minimum of 5+ years of relevant purification process development, preferably in a biopharmaceutical industry setting

  Required Skills:

  • Must have basic knowledge of protein chemistry and protein purification principles
  • Must have hands on protein purification experience using AKTA systems and software or similar
  • Must have hands on filtrations experience, including depth, normal and tangential flow filtrations
  • Must have hands-on experience with basic protein analytical techniques including concentration measurements and purity analysis by SDS-PAGE, HPLC or similar
  • Has the ability to learn new technologies fast and identify new scientific concepts to advance purification process development
  • Is highly self-motivated and has hard-working attitude with ability to own and drive projects to success
  • Has excellent teamwork, communication, and time management skills
  • Is proficient in Microsoft Office (or related) programs

  Desired Skills:

  • Experience with biopharmaceutical process development in the biotech or pharmaceutical industry
  • Experience with monoclonal antibody purification process development
  • Experience with DNA, RNA and viral vector purification considered a plus.
  • Experience in UV-Vis and fluorescence-based assays for oligonucleotide analysis a plus
  • Experience with high throughput process development strategies and liquid handling workstations a plus
  • Knowledge of design of experiment (DOE) a plus
  • Analysis of data using statistical analysis software such as JMP or similar a plus

  Why AstraZeneca?

  At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognising their potential. Join us on our journey of building a new kind of organisation to reset expectations of what a bio-pharmaceutical company can be. This means we’re opening new ways to work, pioneering cutting edge methods and bringing unexpected teams together. Interested? Come and join our journey.

  So, what’s next!

  Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available and we hope it’s yours.

  Where can I find out more?

  Our Social Media, Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/

  Follow AstraZeneca on Facebook https://www.facebook.com/astrazenecacareers/

  Follow AstraZeneca on Instagram https://www.instagram.com/astrazeneca_careers/?hl=en

  Date Posted

  11-Jul-2023

  Closing Date

  AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.

  AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.

• About the company

  AstraZeneca PLC is a British-Swedish multinational pharmaceutical and biopharmaceutical company with its global headquarters in Cambridge, England.

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