• Job Description

  Req#: 4886740

  ROLE SUMMARY

  Pfizer Machine Learning Computational Sciences (MLCS) group has an opening for a computational methods developer with expertise in molecular modeling, Artificial Intelligence (AI), Machine Learning (ML), and scientific programming. The successful candidate will identify novel and creative applications of AI/ML and develop cutting-edge predictive and interpretable models to advance discovery and development efforts across Pfizer. This is an exciting opportunity to join a growing group of computational scientists and machine learning researchers who are passionate about developing novel computational methods and ML models to address challenging problems from early discovery to late-stage development and across established (small molecule and antibody) and emerging (mRNA therapeutics and gene therapy) therapeutic modalities.

  ROLE RESPONSIBILITIES

  • Apply and extend the latest deep learning-based structure prediction methods to model T-cell receptors (TCR) and TCR-peptide-MHC complexes, supporting an interdisciplinary effort to explore potential therapeutic applications of TCRs.
  • Collaborate with colleagues from diverse scientific background to identify problems and opportunities; combine techniques from computational chemistry, computational biology, and AI/ML, particularly utilizing recent deep learning techniques, to rapidly develop powerful computational solutions.
  • Effectively utilize relevant public and proprietary databases and available computational resources (internal HPC and Cloud) to develop predictive models to assess pharmacological and developability properties of candidate molecules from different therapeutic modalities (small molecules, antibodies, mRNA etc).
  • Leverage proprietary computational framework and applications to deploy ML models and other tools for wide usage by Pfizer scientists.
  • Communicate and explain computational models and ML algorithms to broad scientific audience from diverse discipline.
  • Remain current with relevant scientific literature; proactively identify, assess, and internalize promising methods and tools from external sources.
  • Strengthen Pfizer’s external visibility and scientific reputation of excellence through publications in high-impact scientific journals and presentations at external conferences.

  BASIC QUALIFICATIONS

  • Ph.D. in computational chemistry, computational biology, physical or biological sciences, chemical engineering, computer science, or related discipline.
  • Proficiency in Python; experience with scientific programming and algorithm design related to machine learning.
  • Practical hands-on experience with developing predictive models using modern deep learning techniques (e.g., CNNs and transformers) and packages (e.g., PyTorch, TensorFlow, JAX).
  • Track record of applying machine learning, in particular modern deep learning approaches, to solve relevant biological problems.
  • Proficiency in general molecular modeling techniques and familiarity with concepts, techniques, and common tools used for sequence analysis and protein structure modeling.
  • Experience with Unix/Linux and HPC environments.
  • Excellent communication and interpersonal skills.

  PREFERRED QUALIFICATIONS

  • Strong publication record and demonstrated contribution of the machine learning field, e. g. NeurIPS, ICML, ICLR, etc.
  • Demonstrated track record of applying several AI/ML techniques such as ConvNet, transformers, generative modeling, and reinforcement learning to tackle complex drug discovery and development problems.
  • Experience in applying ML to immunology problems such as modeling of HLA-peptide and HLA-peptide-TCR structure and binding.

  
  Additional Information:

  • Relocation Support Available
  • Eligible for employee referral
  • Work Location Assignment: On Premise
  • On Premise colleagues work in a Pfizer site because it’s needed to get their job done. They may have flexibility to work remotely from time to time, but they are primarily on-site.
  • Last Day to Apply: October 16, 2023

  
  

  The annual base salary for this position ranges from $96,900.00 to $161,600.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 15.0% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

  Relocation assistance may be available based on business needs and/or eligibility.

  Sunshine Act

  Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

  EEO & Employment Eligibility

  Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

  Information & Business Tech

• About the company

  At Pfizer we know that great things happen anywhere people come together with one shared goal. And the greatest rewards are sometimes where you least expect them. The future of medicine is happening at Pfizer.

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