• Job Description

  Req#: R-180136

  Senior Scientist, Bioscience

  Gaithersburg, MD

  What is Happening at AstraZeneca

  At AstraZeneca, we work together across global boundaries to make an impact and find answers to challenges. We do this with the utmost integrity even in the most difficult situations because we are committed to doing the right thing. We continuously forge partnerships that help pursue world-class medicines in new ways, combining our people’s exceptional skills with those of people from all over the globe. We turn ideas into life changing medicines. Working here means being ambitious, thinking big and working together to make the impossible a reality.

  This Opportunity

  We are seeking a highly motivated and independent Senior Scientist with scientific and technical expertise in Cell Therapy and/or T-cell biology to join our growing Cell Therapy Engineering group in Gaithersburg, MD. Within this position, your work will develop novel cell therapy platforms and products by integrating protein engineering and synthetic biology with T-cell immunology. You will design and conduct laboratory experiments, develop methodology and then interpret and utilize your scientific data to further develop our technology and products.

  Typical Accountabilities

  • Independently conducts in vitro immunologic drug discovery experiments by applying techniques of molecular and cellular biology.
  • Conducts hands-on primary immune cell culturing and immune functional assays.
  • Proactively contributes to experimental plans and designs.
  • Supports a team and works collaboratively with project managers to ensure the efficient relay of information and forward translation of data.
  • Maintains a well-developed understanding of approaches to drug discovery and applies a broader functional knowledge of the procedures used by diverse project groups to support the department where needed.
  • Assesses and reports data, with little or no guidance, in a clear and concise manner, with a clear understanding of its implications within the overall context of drug discovery.
  • Provides technical instruction to the team and allocates administrative work where possible.
  • Shares and discusses relevant external literature with peers.
  • Communicates and shares information between projects within the Bioscience function and across other functions.
  • Ensures own work, and work of peers, is compliant with Good Laboratory Practice, Safety, Health and Environment standards and all other relevant internal AstraZeneca standards and external regulations.

  Essential Requirements (education, experience and skills):

  • BS and 10+ years or MS and 8+ years of relevant experience, or a PhD in Immunology or equivalent and/or professional certifications with 0-3 years of post-doctoral training in immunology or T cell biology.
  • Well-developed understanding and expertise in molecular and cellular biology of T lymphocytes, especially T-cell ontogeny and signal transduction.
  • Design and performance of functional assays, cell transfection/ transduction related to T-cell biology.
  • Expertise in multi-color flow cytometry experiment design, acquisition, and analysis (30+ colors and phospho/intracellular).
  • Proficiency in cell culture of established cell lines and primary human immune cells
  • In vivo experience, including study design.

  Desired Qualifications

  • Familiarity with gene editing techniques (e.g. CRISPR/Cas, viral engineering, base editing, etc.).
  • Expertise with CAR-T engineering.
  • Extensive experience reflected in high quality publications and/or developing pipeline projects in a pharmaceutical or biotechnology setting.
  • Prior industry experience.

  About Our Gaithersburg Oncology Hub

  Our Gaithersburg, Maryland facility creates life-changing medicines for people around the world. This campus employs more than 3,500 experts in our field and is only a short drive from Washington, DC. This modern and vibrant scientific campus is the home of R&D and Oncology in the US. Here, we host some of the most pioneering technology and lab spaces, all designed to inspire collaboration and cross-functional science. We are dedicated to creating a culture of inclusion and collaboration.

  The Gaithersburg site offers a variety of amenities to help keep our employees happy and healthy. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria, copy center, game rooms, community garden, and much more. This is where you’ll find newly-designed, activity-based work spaces to suit a variety of working styles while growing collaboration between teams.

  When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform to connect, work at pace and challenge perceptions. That’s why we work, on average, a minimum of three days per week from the office. But that doesn’t mean we’re not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

  So, what’s next?

  Are you already imagining yourself joining our team? Good, because we can’t wait to hear from you!

  If you’re curious to know more, please contact Bobbi Poole, our Talent Acquisition Partner.

  Closing Date: March 31, 2024

  Competitive remuneration and benefits apply

  We offer a competitive Total Reward program including a market driven base salary, bonus and long term incentive. We have a generous paid time off program and a comprehensive benefits package.

  Where can I find out more?

  Our Social Media, Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/

  Follow AstraZeneca on Facebook https://www.facebook.com/astrazenecacareers/

  Follow AstraZeneca on Instagram https://www.instagram.com/astrazeneca_careers/?hl=en

  AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We follow all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

  We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

  Date Posted

  01-Mar-2024

  Closing Date

  30-Mar-2024Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.

  AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.

• About the company

  AstraZeneca PLC is a British-Swedish multinational pharmaceutical and biopharmaceutical company with its global headquarters in Cambridge, England.

Notice