Senior Scientist (Cell Culture & Fermentation Sciences)

Introduction to the Group:

Join our Biopharmaceutical Development group, a multi-disciplinary scientific function providing expertise in Process/Analytical/Formulation/Device Development and Characterization. We are also responsible for transferring the processes to different commercial sites in and outside the AstraZeneca organization. Our Cell Culture and Fermentation Sciences Group is accountable for cell line development, process development, and process characterization. This group is also responsible for the scale-up and technical transfer of processes to different clinical and commercial sites and supports manufacturing deviations and regulatory submissions as needed.

Accountabilities:

As a Senior Scientist in the Cell Culture & Fermentation Sciences group, you will work alongside a team of experienced bioprocess development scientists supporting projects across our portfolio. You will develop and optimize mammalian cell culture seed train, bioreactor process, and implement state-of-the-art process technology, including process analytical technology (PAT). You will also develop and improve cell culture media and nutrient feed. Your role will involve designing experiments and the statistical analysis of data. You will support technology transfers to clinical and commercial manufacturing sites including Contract Manufacturing Organizations (CMOs) and be responsible for authoring and reviewing development reports and contributing to regulatory filings such as IND and BLA. In addition, you will engage with the Data Science and Modeling group to transform our ways of working, identify areas for improvement in existing laboratory automation, informatics tools, and workflow using novel cell culture technologies. The position may require weekend work.

Education & Experience Requirements:

Education: BS, MS, or PhD in Chemical/Biochemical Engineering or related field

Experience: BS degree and 7+, MS degree and 5+, or a PhD and 0+ years of relevant industry experience

Essential Skills:

• Experience in cell culture and bioreactor operation

• Strong background in experimental design and data analysis with the ability to evaluate and interpret complex data sets

• Solid understanding of biochemical engineering concepts and biochemical pathways

• Proficiency in Microsoft Office (or related) programs

• Excellent teamwork and communication skills including proven technical writing skills

• Capable of making independent decisions

• Ability to handle multiple projects and / or tasks concurrently in a fast-paced environment

Desirable Skills:

• Knowledge of design of experiment (DOE)

• Data analysis and visualization using statistical analysis software such as JMP

• Data analytics modeling, simulation, and prediction to improve process understanding

• Experience using ambr bioreactor or similar high throughput tools

• Experience and knowledge in multiple areas of focus (Robotics, Informatics, Machine Learning/AI, IT)

Why AstraZeneca?

At AstraZeneca, we are dedicated to improving the lives of patients who need it the most. We are always moving forward, searching for new solutions, and embracing global opportunities. We value dedication, motivation, and courage. We are comfortable working in a risky and dynamic medicine development phase, drawing from diverse minds to find the best path to success. We are always expanding our knowledge to get a broad perspective. It allows us to leverage and fuse our own skills with others to improve impact. We are always improving, supported by our leaders and team, we have the freedom to work on initiatives that benefit ourselves, the business, and ultimately our patients.

Are you ready to make an incredible impact? Join us at AstraZeneca, where your work is recognized across the enterprise, and externally too. Apply today!

Date Posted

23-Apr-2024

Closing Date

Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.

AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.