Job Summary:

We are seeking a highly-motivated and independent in vivo Sr. Scientist with demonstrated experience in Cellular Therapy, Immunology, and/ or Immuno-Oncology to join our rapidly growing Cell Therapy Team. Working in this laboratory-based position, you will make use of your in vivo and in vitro experience in T cell immunology to develop, design, conduct and analyze experiments to assess the function and mechanism of action of innovative Cell Therapy and immuno-oncology products.

Accountabilities:

• Conducts hands-on in vivo research and contributes to the plans and designs of in vivo studies

• Conducts routine drug discovery research experiments independently by applying the techniques of molecular and cellular biology, communicates the results to team members and is involved in the interpretation of data

• Supports a team and works collaboratively with project managers to ensure the efficient relay of information and forward translation of data

• Assesses and reports data, with little or no guidance, in a clear and concise manner, while developing an understanding of its implications within the overall context of drug discovery

• Provides technical instruction to the team and allocates administrative work where possible

• Communicates and shares information between distinct projects within the bioscience function and across other functions

• Ensures own work, and work of peers, is compliant with Safety, Health and Environment standards and all other relevant internal AstraZeneca standards and external regulations

Education, Qualifications, Skills and Experience :

Essential:

• Bachelor’s with 10+ yrs or M.S with 3+ yrs or Ph.D. with scientific experience in a relevant discipline with demonstrated experience in Cellular Therapy, Immunology, and/ or Immuno-Oncology

• Extensive in vivo skillset including animal handling, syngeneic murine, xenograft and PDX tumour models, standard routes of dosing and engraftment, tissue processing, PK/PD and efficacy studies.

• Experience with modelling multiple drug combination studies

• Well-developed understanding of molecular and cellular biology, immunological assays, and cell transfection/ transduction

• Ability to design, execute, and troubleshoot experiments, and to review, analyse, and interpret results

• Team player who is well organized with interpersonal skills in both oral and written and oral communication

Desirable :

• Experience with a range of in vitro assays, including but not limited to ELISA, multicolor flow cytometry, immunoblotting, PCR.

• In vitro and in vivo experience with murine T cells

• Basic experience developing cellular therapies including CAR-T/ CAR-NK, TCR-T, and/ or TIL therapies

• Background in drug discovery and development in the pharmaceutical industry

• Experience with complex in vivo systems, including but not limited to orthotopic xenograft models, in vivo imaging of luciferase labelled tumor models.

• Experience with humanized mouse model systems

About AstraZeneca:

AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development, and commercialisation of prescription medicines for some of the world’s most serious diseases. But we’re more than one of the world’s leading pharmaceutical companies.

At AZ, we’re proud to have an exceptional workplace culture that encourages innovation and collaboration. Here, employees are empowered to express diverse perspectives – and made to feel valued, energized and rewarded for their ideas and creativity. AZ is a place where passionate people can immerse themselves in their work and make significant contributions to scientific excellence and medicines – does this describe a place where you would like to work?

Our Gaithersburg, Maryland facility creates life-changing medicines for people around the world. This campus employs more than 3,500 experts in our field and is only a short drive from Washington, DC. This modern and vibrant scientific campus is the home of R&D and Oncology in the US. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We believe employees benefit from being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration.

The Gaithersburg site offers a variety of amenities to help boost productivity and help keep our employees happy and healthy. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center. This is where you’ll find newly-designed, activity-based work spaces to suit a variety of working styles while increasing collaboration between teams.

“ When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform to connect, work at pace and challenge perceptions. That’s why we work, on average, a minimum of three days per week from the office. But that doesn’t mean we’re not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world .”

Date Posted

08-Mar-2024

Closing Date

07-Apr-2024Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.

AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.