• Job Description

  Req#: 202310-123142

  The Position

  Senior Scientist- DevSci Complex in Vitro Systems

  We are looking for a Scientist to join the Complex in Vitro Systems lab within the department of Safety Assessment to develop, characterize, and qualify complex in vitro models to support Genentech’s mission of developing safe and efficacious new drugs. In addition to working toward the Safety Assessment department’s goals to evaluate drug safety, the CiS group also partners across functions in Development Sciences, Translational Medicine, and Research to develop and implement new models for novel therapeutic evaluation. The CiS group deploys and develops organoid models and state-of-the-art in vitro microphysiological systems (MPS), such as organs-on-chip, to support organization-wide target assessment, lead optimization, and issue mitigation. We establish new platforms and technologies to support a constantly changing portfolio, novel modalities, and emerging therapeutic area needs.

  In particular, the individual will be responsible for providing scientific and technical expertise to drive the development and implementation of MPS models of the blood-brain barrier and neurovascular unit to support drug development. We are looking for a highly motivated candidate with extensive cell culture and organoid modeling experience, particularly with human cerebral organoids and neural assembloid models. Duties will include culturing and characterizing various neurovascular and neural MPS systems and performing model characterization studies (e.g. by microscopy, transcriptomics. etc), analyzing, interpreting results, keeping detailed documentation, sharing scientific insights, and contributing to publication efforts. This is an ideal position for a candidate who wants to be at the forefront of 3D tissue modeling technologies, who thrives in a fast-paced, diverse research environment, and has excellent communication skills that can span functional areas and organizations.

  Responsibilities

  • Establishing tissue models of the blood-brain barrier, neural cortex, and brain, and driving cross-functional implementation of these models. Experience in developing and using these models is required.

  • Designing experiments to characterize models, including barrier properties, cytotoxicity, or electrophysiological behavior, using techniques such as viability assays, confocal microscopy, and high-content imaging. Experience with these methodologies is highly desirable.

  • Utilizing state-of-the-art biofabrication techniques, such as bioprinting and engineering novel biomaterials, to develop new fit-for-purpose neurological models. Experience with biomaterials or biofabrication techniques is highly desirable.

  • Working collaboratively, applying problem-solving skills, and communicating clearly in verbal and written forms

  • Analyzing, interpreting, and presenting data to collaborators, stakeholders and outside meetings as appropriate

  • Maintaining detailed electronic documentation related to departmental SOP adherence, execution, and results, and contributing to final reports as appropriate

  • This role will involve sitting and standing for extended periods, performing some repetitive tasks, and working with potentially hazardous materials including, but not limited to, chemotherapeutics, biological hazards, and human primary cells.

  Skills and Requirements

  • PhD degree in bioengineering, biology, physiology, pharmaceutical sciences or related discipline is required; compensation and title commensurate with experience.

  • 0-2 years experience with hypothesis-driven research in industry or academia; compensation and title commensurate with experience

  • Extensive experience with culturing neural cell types and complex models, including iPSC-derived neurons, glia, and brain organoids, in addition to isolated primary cells.

  • Experience with biomaterials (rheology, gels, etc) and biofabrication (bioprinting, soft lithography etc) is preferred, especially in the context of utilization in MPS systems e.g. organ on chip.

  • Familiarity with quantitative and qualitative techniques such as qRT-PCR, RNA-seq, immunofluorescence (IF) / confocal microscopy, time-lapse microscopy, high-content screening and image analysis is desirable.

  • Strong experimental design, troubleshooting, and protocol optimization skills

  • Meticulous, pays attention to detail, with strong observational skills

  • Strong organizational and communication skills are necessary; experience writing detailed SOPs

  • Ability to analyze, integrate, and clearly communicate/present data to colleagues is required

  The expected salary range for this position based on the primary location in California is $120,700- $224,100. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.

  Benefits

  Who we are

  A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 40 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. Genentech has multiple therapies on the market for cancer & other serious illnesses. Please take this opportunity to learn about Genentech where we believe that our employees are our most important asset & are dedicated to remaining a great place to work.

  Diversity and Inclusion (D&I) are critical to the success of our company and our impact on society. We believe that by championing diversity of background, thought and experience, we can foster a sense of belonging and provide an environment where every employee feels valued, included, and able to contribute their best for the patients we serve. We’re focused on attracting, retaining, developing and advancing our people to their full potential by rewarding bold ways of thinking and integrating inclusive behaviors into every aspect of our work.

  Genentech is an equal opportunity employer, and we embrace the increasingly diverse world around us. Genentech prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status. For more information about equal employment opportunity, visit our Genentech Careers Homepage.

  If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants .

• About the company

  606018 F. Hoffmann-La Roche AG is a Swiss multinational healthcare company that operates worldwide under two divisions: Pharmaceuticals and Diagnostics.

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