Job Title: Senior Scientist, Oncology Safety Science

Introduction to role:
Are you ready to make a significant impact in the field of Oncology? We are seeking a highly motivated Senior Scientist who will contribute to the discovery of novel oncology medicines that include T Cell Engagers and Antibody Drug Conjugates for haem and solid tumor indications. This is an opportunity to be part of a team where you are empowered to follow the science and make a difference in the lives of patients worldwide.

Accountabilities:
As a Senior Scientist, you will design and implement experimental strategies to improve our investigative toxicology capabilities and drive our safety science forward to advise the design and selection of drug candidates with the “right safety” profile. You will also maintain technical expertise in preclinical safety approaches applied to Immuno-Oncology therapeutics or Antibody Drug Candidates and awareness of industry trends.

Requirements:

- Masters in immunology, cancer biology, cell biology, toxicology, pharmacology, or related field with 5+ years experience preferably in industry or academic setting.
- A strong scientific track record with experience of independent research in industry, biotech, or academic setting, working with relevant T Cell Engagers or Antibody Drug Conjugates.
- Experience with in vitro cellular biology/immunology assays applied to physiologically relevant human cellular models, flow cytometry, multiplex cytokine measurements, activation and cytotoxicity assays, micro-physiological systems, 3D organoids, membrane protein arrays, omics technologies, confocal imaging.
- Experience with the design and execution of in vivo studies to determine the effects of T Cell Engagers or Antibody Drug Conjugates on biological systems with line of sight to human safety may be considered an advantage.
- The ability to build an understanding of biology around novel drug targets and pathways, develop testable hypotheses, and drive scientific learning.

Desirable Skills/Experience:

- PhD in immunology, cancer biology, cell biology, toxicology, pharmacology, or related field with experience preferably in industry or academic setting.
- A collaborative, team-oriented approach, able to take on problems in a goal-focused fashion with capacity to coordinate tasks across multiple projects.
- Excellent communication, presentation, interpersonal and influencing skills across levels/subject areas with a strong desire to drive personal development within an industry setting.

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That’s why we work, on average, a minimum of three days per week from the office. But that doesn't mean we’re not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

Why AstraZeneca?
At AstraZeneca, we are driven by our desire to understand and reveal new insights. We are free from fear of failure, free to ask the right questions, make bold decisions, and dig deep into the biology of complex disease. We are always listening and learning from people who live with the diseases our medicines treat. It enables us to better understand their needs and, ultimately, diagnose and design the right treatments to impact patients' lives. We are harnessing digital, data science & AI to help us achieve the next wave of breakthroughs. to do things that have never been done before.

Ready to make a difference? Apply today and join our team in the fight against cancer!

Date Posted

21-Mar-2024

Closing Date

29-Apr-2024Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.

AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.