• Job Description

  Req#: R-183084

  Senior Scientist – Protein Engineering and Structural Biology

  Location: Gaithersburg, Maryland, United States

  Job ID: R-183084

  Date posted: October 23, 2023

  AstraZeneca Pharmaceuticals LP is seeking a Senior Scientist – Protein Engineering and Structural Biology in Gaithersburg, MD.

  AstraZeneca is an exciting company with long-standing tradition of excellence in drug discovery that offers a fantastic culture and great opportunities to enhance your skills and grow your career. At AstraZeneca, we put patients first and strive to meet their unmet needs worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you’re our kind of person.

  Responsibilities

  • Plan and execute experiments related to developing protein engineering platforms for therapeutic antibody generation and optimization.

  • Create research plans, execute experiences, analyze and interpret data and present results to the group and the department.

  • Design, clone and sequence novel protein therapeutics using structural modeling.

  • Transfect and purify proteins/antibodies in bacterial and/or mammalian systems.

  • Optimize protein therapeutic modalities for affinity improvements and robust developability properties through structure-guided modeling and protein engineering wet work.

  • Design and execute experiments to evaluate novel protein therapeutics.

  Requirements

  • PhD in Biotechnology/Biochemistry or related pharmaceutical sciences field, plus 3 years of experience as Researcher/Scientist in biotechnology/pharmaceutical field.

  • Must have experience with: protein expression, characterization and purification; designing experiments, developing assays, optimizing protocols and interpreting experimental results; protein and antibody engineering; antibody selection techniques; and molecular biology techniques.

  About AstraZeneca in Gaithersburg, MD:

  Our Gaithersburg, Maryland facility creates life-changing medicines for people around the world. This campus employs more than 3,500 experts in our field and is only a short drive from Washington, DC. This modern and vibrant scientific campus is the home of R&D and Oncology in the US. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We believe employees benefit from being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration.

  The Gaithersburg site offers a variety of amenities to help boost productivity and help keep our employees stay happy and healthy. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center. This is where you’ll find newly designed, activity-based workspaces to suit a variety of working styles while increasing collaboration between teams.

  “When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform to connect, work at pace and challenge perceptions. That’s why we work, on average, a minimum of three days per week from the office. But that doesn’t mean we’re not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.”

  AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

  AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.

  Date Posted

  23-Oct-2023

  Closing Date

  22-Oct-2023

  AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics (e.g. race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status). We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.

  AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.

• About the company

  AstraZeneca PLC is a British-Swedish multinational pharmaceutical and biopharmaceutical company with its global headquarters in Cambridge, England.

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