• Job Description

  Req#: 382706BR
  INTERNAL ROLE TITLE: Senior Scientist, LVV Upstream Early Process Development
  
  LOCATION: Cambridge, MA
  
  About this role:
  The Senior Scientist, Upstream Early Process Development (USP), will be responsible for advancing scalable process development for suspension-based production of lentiviral vectors and support production of lentiviral vectors for preclinical studies and other development purposes. The candidate will participate in establishing, operating, and troubleshooting suspension shake flask and benchtop bioreactor-based cell culture processes for manufacturing of lentivirus gene therapy vectors across multiple preclinical programs and disease areas.
  
  Key responsibilities:
  • Perform hands-on cell culture expansion, transfection, and viral harvest as well as process scale-up and optimization. Support critical operations as needed in our viral production lab and deliver materials for pre-clinical and clinical studies.
  • Craft and execute experiments to drive innovative technology and platform evaluation for next generation lentiviral gene therapy vectors (LVV) and work with downstream process development and analytical development teams to implement a robust process for the production of high quality LVV.
  • Work with cell line development, viral characterization and formulation colleagues to develop an optimized workflow for next generation LVV manufacture and analytics.
  • Provide technical support, training, and SME knowledge to assist with the development of junior associates. Expand the technical capabilities of the Process Development group by offering expertise in areas such as technology development, platform, or systems development.
  • Prepare protocols, SOPs, technical reports and provide high quality data and electronic notebook documentation.
  
  
  The pay range for this position at commencement of employment is expected to be between $92,800 and $139,200 / year; however, while salary ranges are effective from 1/1/23 through 12/31/23, fluctuations in the job market may necessitate adjustments to pay ranges during this period. Further, final pay determinations will depend on various factors, including, but not limited to geographical location, experience level, knowledge, skills and abilities. The total compensation package for this position may also include other elements, including a sign-on bonus, restricted stock units, and discretionary awards in addition to a full range of medical, financial, and/or other benefits (including 401(k) eligibility and various paid time off benefits, such as vacation, sick time, and parental leave), dependent on the position offered. Details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.
  
  

• About the company

  At Novartis, we are reimagining medicine to improve and extend people’s lives. We are working hard to produce breakthroughs and address unmet needs for patients with devastating diseases, including genetic disorders and certain deadly cancers. Learn mo...

Notice