• Job Description

  Req#: 202307-117551

  The Position

  At Roche, we believe it’s urgent to deliver medical solutions right now – even as we develop innovations for the future. We are passionate about transforming patients’ lives and we are confident in both decision and action. And we believe that good business means a better world. That is why we come to work each day. We commit ourselves to scientific rigour, unassailable ethics, and access to medical innovations for all. We do this today to build a better tomorrow.
  

  The Neuroscience and Rare Disease group in Basel is responsible for the identification and validation of targets, the selection and characterization of drug candidates, as well as the scientific aspects of projects aiming at the identification of new medicines for diseases of the central nervous system. Our task is to support ongoing research projects using molecular pharmacological and chemoproteomic methods in order to understand the mode of action of novel compounds.
  

  The Position

  We are looking for a highly motivated intern (Master student level) to join the Neuroimmunology Section in the Neuroscience and Rare Disease (NRD) Discovery and Translation Area (DTA) at Roche. A major focus of the Neuroimmunology drug discovery team is to explore mechanisms leading to and resolving neuroinflammatory processes in order to develop novel therapies for neurodegenerative disorders. The successful candidate will work under supervision of established scientists in an industry-leading Neuroscience department with an attractive portfolio of preclinical and clinical stage projects in CNS disorders. The position will be based in Basel, Switzerland.
  

  As an Intern in the Neuroscience Discovery group you will:

  • Culture and characterize human primary and iPSC-derived microglia and macrophages

  • Establish and implement novel differentiation protocols for these cells

  • Evaluate cells in biochemical as well as functional assays

  • Prepare samples for unbiased Omics (transcriptomics, proteomics) approaches

  • Analyze data and present results at lab meetings

  • Perform work according to established internal safety guidelines and procedures

  • Work as part of a multi-disciplinary team
    

  During the internship, you will:

  • Use cutting-edge technology

  • Integrate into the Neuroimmunology section

  • Be a member of the Roche Interns Network that offers you chances to connect, have fun and get to know Basel

  • Report to scientists who will be your mentors and supervisors

  • Conduct your laboratory research and work in a small team composed of 4-5 biologists

  
  Who you are

  Your career interests are in Neurobiology/Neuroscience and/or NeuroImmunology and you are motivated to learn new techniques to explore mechanisms underlying progression of neurodegenerative disorders.

  You are / have:

  • Biology, biochemistry or molecular biology student, about to complete or have already completed a Master’s degree program in the last 12 months.

  • An interest in pre-clinical models of neurodegeneration/neuroimmunology and glial cells

  • Solid understanding of cell biology and immunology

  • Practical experience with mammalian cell culture. Previous experience with cultivation and differentiation of iPSC-derived cells will be considered a plus

  • Experienced in molecular and biochemical assays (qRT-PCR / Western blot / ELISA)

  • Skills in imaging and flow cytometry will be considered a plus

  • Experience with data analysis tools like Prism and FlowJo will be a plus

  • A self-motivated and independent thinker with excellent communication skills, attention to detail, and the desire to work in a fast-paced, cutting-edge environment

  • Fluent in English (writing and speaking)
    

  We expect outstanding motivation, creativity, analytical thinking and a strong dedication to productivity.

  The preferred start date of the internship is November 2023. Please clearly indicate your preferred starting date of internship in your motivation letter. Applications need to include a CV and a motivation letter. Optional: Reference letters, transcripts, etc.

  Due to regulations non-EU/EFTA citizens must provide a certificate from the university stating that an internship is mandatory as part of the application documents.

  Who we are

  At Roche, more than 100,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.

  Basel is the headquarters of the Roche Group and one of its most important centres of pharmaceutical research. Over 10,700 employees from over 100 countries come together at our Basel/Kaiseraugst site, which is one of Roche`s largest sites. Read more.

  Besides extensive development and training opportunities, we offer flexible working options, 18 weeks of maternity leave and 10 weeks of gender independent partnership leave. Our employees also benefit from multiple services on site such as child-care facilities, medical services, restaurants and cafeterias, as well as various employee events.

  We believe in the power of diversity and inclusion, and strive to identify and create opportunities that enable all people to bring their unique selves to Roche.

  Roche is an Equal Opportunity Employer.

• About the company

  606018 F. Hoffmann-La Roche AG is a Swiss multinational healthcare company that operates worldwide under two divisions: Pharmaceuticals and Diagnostics.

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