• Job Description

  Req#: REQ-24887

  Job Description

  General Summary:

  The Manufacturing Science & Technology (MSAT) Drug Product team is responsible for managing small molecule drug product from new product launch through commercial production. This involves commercial process validations, technology transfers as well as being accountable for commercial production. Vertex manages its portfolio of products using both internal and external manufacturing options, meaning the position involves collaboration across different disciplines and organizations.

  This is a Boston based hybrid position (3 days/week onsite).

  Key Duties and Responsibilities:

  • Recognized as a subject matter expert and acts as a resource in one or more technical areas
  • Represents department on cross-functional CMC teams, with minimal guidance, to influence late stage process/product development and minimize subsequent commercialization risk
  • Develops and executes manufacturing strategies for Technology Transfers and Process Validations, including formulation of strategic master plans, protocols and reports
  • Ensures positive and effective relationships with key suppliers of materials, technology, and manufacturing resources
  • Evaluates process performance using statistical process controls to identify and lead continuous improvement activities throughout the product lifecycle
  • Resolves complex manufacturing issues and supports resolution of quality investigations and implement corrective actions related to tech transfer and commercial manufacturing
  • Ensure risk-based process improvements, driving efficiency and cost-effectiveness while maintaining compliance
  • Drive a culture of technical excellence, problem-solving, and continuous improvement; participate in technical team discussions, contributing to long term technical strategy beyond MSAT responsibilities
  • Prepare for and support regulatory submissions and inspections with global health authorities

  Knowledge and Skills:

  • Demonstrated experience with oral solid dosage form and/or commercial spray drying
  • Advanced knowledge of GMP’s and associated CMC regulatory considerations in a pharmaceutical environment
  • Demonstrated experience managing projects in the pharmaceutical industry
  • Strong understanding and application of technology transfer and validation processes
  • Strong communication, collaboration and team building skills; ability to connect with all levels of the organization
  • Demonstrated ability to manage multiple high-priority projects concurrently, and influence in a strong-matrix work environment
  • Mastery with complex data analysis, mathematical modeling and optimization software (like Matlab, JMP, etc.)
  • Knowledgeable in QbD and designed experiment methodology and implementation
  • Polished written and verbal communications skills
  • Ability to navigate and be successful in a fast-paced, highly matrixed work environment.
  • Willingness and Ability to travel domestically and internationally (approximately 30%)

  Education and Experience:

  • Bachelor's degree in pharmaceutical sciences or engineering discipline
  • Requires the following combination of education and experience, PhD and 2+ years, or Master's and 3+ years, or Bachelor's and 5+ years.

  Pay Range:

  $118,300 - $177,400

  Disclosure Statement:

  The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

  At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

  Flex Designation:

  Hybrid-Eligible Or On-Site Eligible

  Flex Eligibility Status:

  In this Hybrid-Eligible role, you can choose to be designated as:
  1. Hybrid: work remotely up to two days per week; or select
  2. On-Site: work five days per week on-site with ad hoc flexibility.

  Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.
  

  Company Information

  Vertex is a global biotechnology company that invests in scientific innovation.

  Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

  Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

• About the company

  Vertex Pharmaceuticals, Inc. is an American biopharmaceutical company based in Boston, Massachusetts.

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