Senior Scientist, Translational Proteomics, Global Mass Spectrometry

Gaithersburg, MD

Join AstraZeneca's Oncology R&D team, where our ambition is to eliminate cancer as a cause of death. We are seeking a motivated scientist to join the Translational Proteomics team within our Cancer Biomarker Development (CBD) group. This is an opportunity to work on the next generation of drug modalities and stay at the forefront of advancements in biotechnology.

Accountabilities:

In this role, you will develop and apply mass spectrometry-based proteomics workflows for biomarker quantification to accelerate the development of AZ’s oncology medicines. You will be responsible for developing and validating innovative DIA-based mass spectrometry proteomics for biomarker studies, processing clinical samples for translational and clinical studies, operating high-resolution LC-MS instruments, analyzing R&D and clinical data, and collaborating with translational biologists and bioinformatics teams to develop protein biomarkers.

Essential Skills/Experience:

• Ph.D. in bioanalytical chemistry or related field with 0-3 years post-doctoral experience in quantitative mass spectrometry-based proteomics.
• Extensive hands-on experience with high-resolution mass spectrometry instrumentation for method development, data acquisition, troubleshooting and quality control.
• Experience with biological sample preparation (tissue, plasma) for quantitative LC-MS applications.
• Expertise in global proteomics data analysis (Skyline, Spectronaut, MaxQuant, DIA-NN) and down-stream interpretation (differential expression, pathway analysis).
• Proficient programming skills (R, Python) and statistics for advanced data analysis and visualization.
• Demonstrated ability to work independently and collaboratively with strong communication skills.

Desirable Skills/Experience:

• Experience with PTM enrichment and quantification in clinical samples.
• Experience with sample preparation with liquid handling robotics.
• Experience working in regulated environments (GCP/GLP).

At AstraZeneca, we push the boundaries of science to change the practice of medicine and transform the lives of patients living with cancer. We are a science-based, leading and decisive Oncology enterprise united in our vision to eliminate cancer as a cause of death. We foster a mindset of courage, where everyone is empowered to step up, innovate and work at pace. Our pipeline is a testament to our growth, both now and in the future. With varied and interesting problems to solve, we get a constant thrill from the challenge. By working with diverse functions, we get exposure to multidisciplinary learning and diverse perspectives.

Ready to make a difference? Apply today!

If you’re curious to know more, please contact Bobbi Poole, our Talent Acquisition Partner.

Closing Date: April 30, 2024

Competitive remuneration and benefits apply

We offer a competitive Total Reward program including a market driven base salary, bonus and long term incentive. We have a generous paid time off program and a comprehensive benefits package.

Where can I find out more-

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AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We follow all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

Date Posted

02-Apr-2024

Closing Date

29-Apr-2024Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.

AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.