Are you an innovative scientist with a background in Toxicology, Immunology, Cell Biology or Pharmacology? Are you passionate about the discovery and development of life-saving medicines? If so, we have an exciting opportunity for you at AstraZeneca! We are looking for a motivated and passionate individual to join us as a Director/Senior Director Toxicologist with a focus on the next generation of transformative immunology drug projects. You will bring critical immunosafety expertise to the Respiratory & Immunology, Neuroscience, Vaccines & Immune Therapies (RINVI), Safety Sciences within the larger function of Clinical Pharmacology and Safety Sciences (CPSS).

Accountabilities:

As an empowered Immunology Toxicologist at AstraZeneca, you will work at the forefront of toxicology and safety science, working in a multidisciplinary and international environment. You will play a key role in progressing our rich and diverse R&I pipeline through discovery, into clinical development and ultimately launch. Your responsibilities include designing and interpreting toxicology research programs, leading the immunological safety and toxicology input to AstraZeneca R&I project teams, evaluating and assessing drug project safety risks and developing risk mitigation strategies. Additional responsibilities include providing expert nonclinical evaluation of in-licensing and out-licensing opportunities, contributing to the delivery of the departmental strategy and objectives, participating in external consortia/symposia, and representing AstraZeneca at relevant scientific venues, and providing mentorship and guidance to early career toxicologists.

Essential Skills/Experience:

• PhD in toxicology, immunology, cell biology, pharmacology, Toxicology, systems biology, or related field.
• Director has 5 plus years of pharmaceutical or biotechnology experience working as a toxicologist.
• Senior Director has 9 plus years of pharmaceutical or biotechnology experience working as a toxicologist, plus experience providing technical oversight and experience leading teams.
• High level of knowledge and expertise in Immunology, toxicology, and immunological assays.
• Established record of scientific contribution in peer-reviewed journals and scientific symposiums.
• Excellent verbal and written communication skills.
• Experience with design of strategies and/or execution of in vitro and/or in vivo experiments to determine the safety and/or efficacy of immunological therapeutics.
• Experience with the nonclinical safety assessment strategy for biologics including bispecific and T cell engager immunomodulatory drugs, immune cell therapy) for Oncology and/or Immunology indications

Desirable Skills/Experience:

• Experience with various other modalities (small molecules, siRNAs, ASOs, ADCs, protacs).
• Expertise in T-cell biology including T reg cells.

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That’s why we work, on average, a minimum of three days per week from the office. But that doesn't mean we’re not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

At AstraZeneca, we are change-makers on the stage at an exciting frontier of medicine. We are helping to transform healthcare and build pandemic preparedness to protect against future health crises. We are committed to our central role in addressing pandemic and endemic diseases and ensuring our products continue to reach and benefit millions of people around the world. We are team players who invest in ground-breaking collaborations, local partnerships, and commercial initiatives. In everything we do, people come first. Every decision and action is centered around how we can serve them better. We are challenging the norm, going above and beyond to find solutions for the people receiving our medicines.

Join us in our dynamic and diverse environment. The Vaccines and Immune Therapies team thrives in a diverse environment. Here we draw on our breadth of knowledge and experience, which as a team reflects the diversity of the populations we seek to protect. It’s how we go beyond the usual collaborative models, connecting our thinking, and relationships and partnerships internally and externally. Crafting a connected ecosystem and problem-solving in an open, inclusive culture.

Are you ready to make a meaningful and lasting difference? Apply today and join us in our mission to push the boundaries of science and transform medicine! For more information, please contact: Per Åberg, Senior Director or Julia Johansson PhD, Senior Director, Respiratory & Immunology, Neuroscience, Vaccine and Immune Therapies (RINVI) Safety Science, per.aberg@astrazeneca.com or Julia.johansson1@astrazeneca.com. We look forward to your application, but no later than 19th April 2024.

Date Posted

14-Mar-2024

Closing Date

18-Apr-2024Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.

AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.