• Job Description

  Req#: 1010407
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  GENERAL SUMMARY/ OVERVIEW STATEMENT:
  The Translational Cancer Immunology (TCI) lab at the Mass General Cancer Center and the Broad Institute seeks a highly motivated and well-organized candidate for a full-time Research Technician position. The candidate will be key in advancing the lab’s research goals to understand the mechanisms driving resistance to immunotherapies using single-cell genomics, functional in vivo CRISPR screens, and mechanistic studies. The lab has been working closely with MGH clinicians to study the immune response in patients with cancer and infections using leading-edge genomics and proteomics methods. In addition, they may use animal and cell culture models to analyze mechanisms of innate and adaptive immunity. The candidate will be responsible for designing and conducting experiments with their supervisor.
  PRINCIPAL DUTIES AND RESPONSIBILITIES: Indicate key areas of responsibility, major job duties, special projects and key objectives for this position. These items should be evaluated throughout the year and included in the written annual evaluation.
  • Isolate immune cells from patient and mouse tumors and contribute to their characterization using advanced methods of single-cell molecular profiling. The candidate would work with primary cells from these tumors.
  • Techniques used will include flow cytometry, cell sorting, cell culture, single-cell RNA-seq, Imaging, PCR, DNA sequence analysis, western blotting, and CRISPR technologies.
  • Independently carries out non-routine, highly specialized experimental procedures in histology, immunofluorescence, flow cytometry, molecular biology, mouse cellular immunology
  • Independently modifies and/or develops techniques and methodologies necessary to meet research and/or experimental needs.
  • Organizes workflow as needed and coordinates the scheduling of experiments.
  • Ordering laboratory reagents and maintaining mouse colonies for tumor immunity studies.
  • Maintain databases for patient-derived clinical specimens.
  • Organizes and accurately maintains written records of experimental procedures and data collection.
  • Contribute to the preparation of manuscripts resulting from data generated in research projects.
  • Performs advanced data analysis using complex software programs and statistical techniques.
  • May teach moderately difficult to complex lab techniques to students and research personnel.
  • Participates in weekly lab and project-related meetings.
  SKILLS/ABILITIES/COMPETENCIES REQUIRED: Must be realistic, objective, measurable and related to essential functions of this job.
  • 1+ years of lab experience, preferably in an Immunology/cancer laboratory
  • Experience with common biological techniques, such as cell culture and DNA/RNA library construction and sequencing, protein analysis, and preferably mouse cellular immunology
  • Strong organizational skills and communication skills
  • Quantitative data analysis skills are highly desirable.
  • Highly self-motivated, reliable, and responsible.
  • Demonstrated analytical and problem-solving skills.
  • Able to work both independently and as a part of a team.
  • Excellent verbal and written communication skills
  • Attention to detail in experimental techniques and record keeping.
  .
  LICENSES, CERTIFICATIONS, and/or REGISTRATIONS (if applicable): Specify minimum credentials and clearly indicate if preferred or required
  EDUCATION: Specify minimum education and clearly indicate if preferred or required
  BS/BA/equivalent degree (or Masters) in biology, cell and molecular biology, Immunology, microbiology, biochemistry or related field in the sciences. Experience as a research technician or leading independent research projects ideal.
  EXPERIENCE: Specify minimum creditable years of experience and clearly indicate if preferred or required
  1+ years of lab experience after college degree
  WORKING CONDITIONS: Describe the conditions in which the work is performed.
  Duties will be performed in a research laboratory. No direct patient contact will occur.
  Work will be conducted over a forty-hour workweek, but the actual schedule can be flexible.
  PRINCIPAL DUTIES AND RESPONSIBILITIES:
  Please note, the functions below are representative of major duties that are typically associated with these positions. Specific responsibilities may vary based upon departmental needs. Similarly, not all duties that have been outlined will be assigned to each position.
  • Prepares basic solutions and performs base-level procedures as assigned (i.e. – pipetting, cell and tissue culture, etc.)
  • Maintains laboratory notebook
  • Understands and applies basic scientific techniques
  • Conducts analysis of results and may begin interpretation of results
  • Sets up and prepares routine experiments as directed
  • Prepares lab reagents, chemicals, instruments and equipment
  • May perform independent literature searches
  • Assists with organizing materials for publication or presentation
  • Maintains and orders supplies
  A Research Technician II performs the duties of a Research Technician I (above) and may also:
  • Execute protocols of non-routine experiments
  • Assist the PI(s) with determining the most suitable methodology
  • Perform basic design and modification of protocols
  • Calculate, transcribe and analyze data
  • Prepare and present reports
  • Organize and summarize acquired data, using scientific and statistical techniques.
  • Organize and/or draft material for the preparation of research papers, manuscripts and other documents for publication and/or presentation.
  • Participate in the design of experiments or field work.
  SKILLS/ABILITIES/COMPETENCIES REQUIRED:
  • Ability to work independently and as a team member
  • Good communication skills
  • Computer literacy
  • Working knowledge of clinical research protocols
  • Ability to perform multiple tasks independently
  The Research Technician II should also possess:
  • Analytical skills and the ability to resolve technical problems
  • Ability to interpret acceptability of data results
  • Working knowledge of data management programs
  • Demonstrated competence in research techniques and methodologies
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  EDUCATION:
  • Bachelor’s degree required.
    
  EXPERIENCE:
  • New graduates with some lab experience (via course work, internships, etc.) or those without any prior research experience will be considered for the Research Technician I position outlined above.
  • Those with a minimum of 1 year of directly related work experience will be considered for a Research Technician II position.
  SUPERVISORY RESPONSIBILITY (if applicable):
  • A Research Technician II may serve as a team leader to lab assistants and Research Technician I’s.
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  Massachusetts General Hospital is an Affirmative Action Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.
  
  MGH Main Campus (MGHMAIN)
  55 Fruit Street
  Boston, 02114
  
  

• About the company

  Mass General Brigham is a Boston-based non-profit hospital and physicians network that includes Brigham and Women's Hospital and Massachusetts General Hospital, two of the nation's most prestigious teaching institutions.

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