• Job Description

  Req#: 202309-119729

  The Position

  Scientist in Bioinformatics and Biocatalysis (Process Chemistry)

  As a scientist in biocatalysis you will be working in the section “Catalysis & Flow Reactions”, which is an integral part of the Process Chemistry & Catalysis department within the Synthetic Molecules Technical Development (PTDC) organization.

  Behind every product sold by Roche is the strong involvement of Pharma Global Technical Operations (PT). Starting with Phase I of the clinical development process and continuing through to product maturity, PT makes medicines at sites around the world and includes more than 12000 employees worldwide.

  Global Technical Development (PTD) is an organization within PT of over two thousand people globally that are integral for the mission of Roche to develop new, efficacious medicines for patients. Therefore, PTD actively collaborates and develops innovative technical solutions to bridge early-stage, late-stage and commercial product needs. The mandate of this unit is to reliably deliver the pipeline and supply quality products to patients. The unit excels in its work through innovation, collaboration, dedication, and mutual respect and adds value every day, continuously improving what it does.

  Synthetic Molecules Technical Development (PTDC) within the PTD unit brings a broad range of experience across drug substance (DS), drug product (DP), analytical sciences and manufacturing science & technology, and collaborates closely with key partners in the departments Research and Early Development (pRED / gRED), commercial manufacturing (PTC) and PTD. PTDC is responsible for late stage technical development of our synthetic molecules pipeline, manufacture of DS and DP for clinical studies, and transfer of the processes to commercial Manufacturing.

  In the Process Chemistry & Catalysis department, we design and develop robust and cost effective Drug Substance processes using state of the art science and methodologies. We deliver the company’s portfolio of small molecules from entry into human through transfer to commercial manufacturing relying as well on the external workbench. This includes the optimal support for regulatory submissions.

  Your Responsibilities

  • You will be responsible to increase the quality and diversity of our enzyme libraries, and predict key amino acid positions for enzyme engineering to increase activity, selectivity and stability using structure-based computational chemistry techniques.

  • You will design and create focused enzyme libraries based on protein structure and experimental data, modelling and simulation to deliver new enzymes that enable an efficient intermediate synthesis/new sustainable “green” synthesis route.

  • You will evaluate the application, development and implementation of novel computational methods to leverage protein structure and experimental data for enzyme library creation and enzyme engineering.

  • You will enable enzyme activity prediction based on the existing data by means of data analysis and machine learning.

  • As part of a project team you will be responsible for the screening (efficient data processing, hit identification and verification) and ultimately the development of enzyme catalyzed processes suitable for manufacturing pharmaceutically active ingredients in high quality.

  Your Qualification

  • As a scientist in Process Development & Catalysis, you hold a PhD degree in in synthetic chemistry, bioinformatics, biocatalysis or molecular biology and have conducted a post-doc on bioinformatics and molecular modeling. These competences are demonstrated by publications in scientific peer-reviewed journals and patents.

  • You are an expert on state-of-the-art bioinformatics, applying phylogenetic analysis of protein families to infer distant homologs and orthologues.

  • You are an expert in sequence modeling, de novo prediction, visualization and analysis of protein structures, in small molecule docking and in molecular dynamics simulations of protein-ligand complexes.

  • You are familiar with data analysis techniques, common databases (SQL and/or MongoDB). Experience with machine learning is a plus.

  • Expertise in state-of-the-art screening techniques for biotransformations including pronounced knowledge in data gathering, mining, visualization IT tools (e.g. Spotfire).

  Who we are

  At Roche, more than 100,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.

  Basel is the headquarters of the Roche Group and one of its most important centres of pharmaceutical research. Over 10,700 employees from over 100 countries come together at our Basel/Kaiseraugst site, which is one of Roche`s largest sites. Read more.

  Besides extensive development and training opportunities, we offer flexible working options, 18 weeks of maternity leave and 10 weeks of gender independent partnership leave. Our employees also benefit from multiple services on site such as child-care facilities, medical services, restaurants and cafeterias, as well as various employee events.

  We believe in the power of diversity and inclusion, and strive to identify and create opportunities that enable all people to bring their unique selves to Roche.

  Roche is an Equal Opportunity Employer.

• About the company

  606018 F. Hoffmann-La Roche AG is a Swiss multinational healthcare company that operates worldwide under two divisions: Pharmaceuticals and Diagnostics.

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