• Job Description

  Req#: R-162289

  Senior Scientist, Mass Spectrometry, Diagnostic Proteomics

  Gaithersburg, MD

  About AstraZeneca

  AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialization of prescription medicines for some of the world’s most serious diseases. But we’re more than one of the world’s leading pharmaceutical companies. A place built on courage, curiosity and collaboration – we make bold decisions driven by patient outcomes. Empowered to lead at every level, free to ask questions and take smart risks that write the next chapter for our pipeline and Oncology team. Make a meaningful impact that brings real benefits to society. By applying your knowledge of data, you will help to redefine our industry and ultimately save lives. Work with experts who share a common goal: to accelerate the potential of medicines and the science of tomorrow.

  What you’ll do

  AstraZeneca is seeking a motivated scientist to join the Diagnostic Proteomics team within our Cancer Biomarker Development (CBD) group located in Gaithersburg, MD. The scientist will develop and apply mass spectrometry-based proteomics workflows for biomarker quantification in clinical samples to accelerate the development of AZ’s oncology medicines. This position requires expertise in quantitative mass spectrometry for clinical samples and strong communication skills to collaborate across multidisciplinary teams.

  • Develop and validate innovative DIA-based mass spectrometry proteomics for biomarker studies.
  • Process clinical samples (e.g., FFPE tissue, frozen tissue, plasma) for translational and clinical studies.
  • Operate high-resolution LC-MS instruments (Exploris 480, TimsTOF Pro2) and ensure high-quality data.
  • Analyze data, summarize results, and present key results internally and externally.
  • Collaborate with translational medicine and bioinformatics teams to develop protein biomarkers.

  Essential for the role

  • Ph.D. in bioanalytical chemistry or related field with 0-5 years post-doctoral experience in mass spectrometry-based proteomics. Candidates with M.S. in bioanalytical chemistry or related field with 4-10 years of post-graduate experience in mass spectrometry-based proteomics are also encouraged to apply.
  • Extensive hands-on experience with LC-MS instrumentation for operation, maintenance, troubleshooting, quality control, and standardization for proteomics workflows.
  • Experience in sample preparation for human biological samples. Experience with liquid handling robotics for automated sample preparation is a plus. Experience with GCP/GLP/GMP is a plus.
  • Deep knowledge of protein quantitation approaches (DIA) applied to clinical applications.
  • Expertise in software for quantitative proteomics (Skyline, Spectronaut, MaxQuant, DIA-NN).
  • Proficient programming skills (R, Python) for advanced data analysis and visualization.
  • Experience in working independently and collaboratively in a matrixed environment with strong communication skills.

  About Our Gaithersburg Oncology Hub

  Our Gaithersburg, Maryland facility creates life-changing medicines for people around the world. This campus employs more than 3,500 experts in our field and is only a short drive from Washington, DC. This modern and vibrant scientific campus is the home of R&D and Oncology in the US. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We are dedicated to creating a culture of inclusion and collaboration.

  The Gaithersburg site offers a variety of amenities to help keep our employees happy and healthy. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center, game rooms, community garden and more. This is where you’ll find newly-designed, activity-based work spaces to suit a variety of working styles while increasing collaboration between teams.

  So, what’s next?

  Are you already envisioning yourself joining our team? Good! We can’t wait to hear from you!

  If you’re curious to know more, please contact Bobbi Poole, our Talent Acquisition Partner.

  Closing date: July 19, 2023

  Competitive remuneration and benefits apply

  We offer a competitive Total Reward program including a market driven base salary, bonus and long term incentive. We have a generous paid time off program and a comprehensive benefits package.

  Where can I find out more?

  Our Social Media, Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/

  Follow AstraZeneca on Facebook https://www.facebook.com/astrazenecacareers/

  Follow AstraZeneca on Instagram https://www.instagram.com/astrazeneca_careers/?hl=en

  AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We follow all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

  We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

  Date Posted

  21-Jun-2023

  Closing Date

  18-Jul-2023

  AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.

  AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.

• About the company

  AstraZeneca PLC is a British-Swedish multinational pharmaceutical and biopharmaceutical company with its global headquarters in Cambridge, England.

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